Method and apparatus for measuring myocardial impairment and dysfunctions from efficiency and performance diagrams

• US 5,810,011 A
• Filed: 02/27/1996
• Issued: 09/22/1998
• Est. Priority Date: 02/27/1996
• Status: Expired due to Fees

• Current Assignee: Sabine Vivian Kunig
• Original Assignee: Sabine Vivian Kunig
• Inventors: Kunig, Sabine Vivian
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/607,789
• Time in Patent Office: 938 Days
• Field of Search: 128/668, 128/691, 128/713, 128/672
• US Class Current: 600/481
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00

Abstract

A diagnostic and monitoring device is used to diagnose myocardial impairment, dysfunctions, and the state of critical illness. The device has utility to design and monitor therapies for differential treatment of myocardial impairment, dysfunctions, rehabilitation, and conditioning exercises. Ventricular size, pressures, and heart rate are measured to determine cardiac efficiency given by volume and pressure efficiency components, cardiac work and myocardial oxygen consumption, the data being displayed in efficiency and performance diagrams to diagnose myocardial impairment from cardiac efficiency data, dysfunctions from myocardial oxygen consumption data, and the state of critical illness from cardiac work data.

Claims

1. A cardiac diagnostic device for monitoring a subject, said device including;

means for measuring physiological parameters of such subject;

means responsive to measurements of physiological parameters of such subject for deriving values of cardiac efficiency and myocardial oxygen consumption;

means for establishing a boundary of physiological criticality in a first reference frame of cardiac efficiency versus myocardial oxygen consumption; and

means using said cardiac efficiency and myocardial oxygen consumption of such subject for establishing a subject data point in said first reference frame whereby a comparison is allowed between said subject data point and said boundary of physiological criticality.

2. The cardiac diagnostic device according to claim 1 wherein said boundary of physiological criticality includes at least one curve in said first reference frame, said curve containing at least one reference point representing an absence of dysfunction and myocardial impairment.

3. The cardiac diagnostic device according to claim 2 wherein said means responsive to said measurements further derives cardiac pressure efficiency and cardiac volume efficiency for such subject;

and wherein said means for establishing a boundary of physiological criticality further establishes at least one cardiac efficiency curve in a cardiac efficiency reference frame of cardiac volume efficiency versus cardiac pressure efficiency, said cardiac efficiency curve containing a basal reference point representing a basal value for cardiac volume efficiency and a basal value for cardiac pressure efficiency;

and wherein said means for establishing a subject data point in said first reference frame further establishes a second subject data point in said cardiac efficiency reference frame using said derived cardiac pressure efficiency and cardiac volume efficiency whereby a comparison is allowed between said second subject data point and said cardiac efficiency curve for the left or right heart.

4. The cardiac diagnostic device according to claim 3 wherein said cardiac efficiency curve consists of a plurality of cardiac efficiency curves in said cardiac efficiency reference frame.

5. The cardiac diagnostic device according to claim 3 wherein said cardiac efficiency is defined as the product of cardiac volume efficiency and cardiac pressure efficiency.

6. The cardiac diagnostic device according to claim 3 wherein said cardiac efficiency curve represents a cardiac basal efficiency value for all values of cardiac volume efficiency and cardiac pressure efficiency.

7. The cardiac diagnostic device according to claim 3 further including using said subject data point and said curve in said first reference frame and second subject data point and said cardiac efficiency curve in said cardiac efficiency frame to design and monitor therapies for differential treatment of myocardial impairment or dysfunction.

8. The cardiac diagnostic device according to claim 3 further including using said subject data point and said curve in said first reference frame and second subject data point and said cardiac efficiency curve in said cardiac efficiency frame to design and monitor exercise programs for cardiac rehabilitation and conditioning of subjects.

9. The cardiac diagnostic device according to claim 2 wherein said means for establishing a boundary includes a second curve establishing a zone of physiological criticality with said at least one curve at which death is imminent.

10. the cardiac diagnostic device according to claim 2 wherein said at least one curve further establishes a basal level of cardiac work expended, and wherein said means for establishing further provides a plurality of curves representing elevated levels of cardiac work expended relative to said basal level.

11. The cardiac diagnostic device according to claim 1 wherein said measurements of physiological parameters include signals representative of ventricular size, ventricular blood pressure, time for completion of one cardiac cycle, and heart rate.

12. The cardiac diagnostic device according to claim 1 wherein said means responsive to physiological measurements of physiological parameters further derives volume efficiency, pressure efficiency, cardiac work and available energy for conversion to cardiac work.

19. the cardiac diagnostic device according to claim 12, wherein said means for establishing further provides a plurality of progression curves each in one progress reference frame, each of said progression reference frames having one of said derived values versus time, said progression curves containing points representing instant values of said derived values or their time derivatives for such subject at different times during a therapy treatment or an exercise program.

13. A method of diagnosing myocardial impairments, dysfunctions and physiological criticality of a subject, said diagnostic method including the steps of:

monitoring such subject to obtain measurements representative of physiological parameters;

determining cardiac efficiency and myocardial oxygen consumption for such subject using said representative measurements;

establishing a boundary of physiological criticality in a first reference frame of cardiac efficiency versus myocardial oxygen consumption;

establishing a subject data point in said first reference frame which represents said determined cardiac efficiency and myocardial oxygen consumption for such subject; and

comparing said subject data point with said boundary to indicate physiological criticality.

14. The method according to claim 13 including the further steps of:

providing at least one curve in said first reference frame containing at least one reference point which represents an absence of dysfunction and myocardial impairment; and

comparing said subject data point to said at least one curve to diagnose myocardial impairments and dysfunctions of the left or right heart of such subject using said reference point of said curve.

15. The method according to claim 14, wherein said diagnosis of impairment is made by comparing the position of said data point with said reference point with respect to said cardiac efficiency of said first reference frame, and wherein said diagnosis of dysfunction is made by comparing the position of said data point with said reference point with respect to said myocardial oxygen consumption of said first reference frame.

16. The method according to claim 14, including the further steps of:

determining cardiac pressure efficiency and cardiac volume efficiency for such subject using said representative measurements;

providing at least one cardiac efficiency curve in a cardiac efficiency reference frame of cardiac volume efficiency versus cardiac pressure efficiency, said cardiac efficiency curve containing an basal reference point representing a basal value for cardiac volume efficiency and a basal value for cardiac pressure efficiency;

establishing a second subject data point in said cardiac efficiency reference frame using said determined cardiac pressure efficiency and cardiac volume efficiency;

comparing said second subject data point with said cardiac efficiency curve to determine more specifically a cardiac condition and to aid in designing therapies affecting said impairments and dysfunctions.

17. The method according to claim 16 wherein said comparison of said second subject data point with said cardiac efficiency curve involves comparing the volume efficiency of said second subject data point with the basal volume efficiency and comparing the pressure efficiency of said second subject data point with the basal pressure efficiency.

18. The method according to claim 16 further including the step of designing and monitoring therapies, exercise rehabilitation programs in response to said step of comparing.