Non-invasive carboxyhemoglobin analyer
First Claim
1. A non-invasive method for measuring the concentration of carboxyhemoglobin in a subject'"'"'s blood, said method comprising the steps of:
- (a) converting the reduced hemoglobin constituent of said subject'"'"'s blood to oxyhemoglobin by providing supplemental oxygen;
(b) directing light of two different wavelengths through a tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, the first of said wavelengths being absorbed substantially equally by the oxy- and carboxyhemoglobin constituents of the subject'"'"'s blood, and the second of said wavelengths being absorbed differentially by the oxy- and carboxyhemoglobin constituents of the subject'"'"'s blood;
(c) detecting the portion of said light of the two different wavelengths that has passed through the arterial blood vessel of said subject;
(d) determining the pulsatile changes in absorbance of the two wavelengths of light by the subject'"'"'s arterial blood;
(e) determining the ratio of change in absorbance of the two wavelengths, and;
(f) calculating the concentration of carboxyhemoalobin in said subject'"'"'s blood by comparing the ratio of change in absorbance of the two wavelengths to ratios measured in subjects with known carboxyhemoglobin levels.
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Accused Products
Abstract
An apparatus and method is disclosed which allows the non-invasive monitoring of a subject'"'"'s carboxyhemoglobin level, thereby allowing the detection of possible carbon monoxide poisoning. The subject breathes oxygen to saturate his blood hemoglobin and eliminate reduced hemoglobin, thus allowing the detection and differentiation between oxy- and carboxyhemoglobin by modification of a conventional pulse oximeter. Preferably the device works in two modes. The first mode is a conventional pulse oximeter capable of determining the level of oxy-hemoglobin in the subject'"'"'s arterial blood. Upon the achievement of certain criteria the preferred embodiment of the inventive device would switch to a second mode, in which mode the device would be capable of determining carboxyhemoglobin levels.
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Citations
20 Claims
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1. A non-invasive method for measuring the concentration of carboxyhemoglobin in a subject'"'"'s blood, said method comprising the steps of:
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(a) converting the reduced hemoglobin constituent of said subject'"'"'s blood to oxyhemoglobin by providing supplemental oxygen; (b) directing light of two different wavelengths through a tissue of the subject in which pulsatile flow of blood through an arterial blood vessel can be detected, the first of said wavelengths being absorbed substantially equally by the oxy- and carboxyhemoglobin constituents of the subject'"'"'s blood, and the second of said wavelengths being absorbed differentially by the oxy- and carboxyhemoglobin constituents of the subject'"'"'s blood; (c) detecting the portion of said light of the two different wavelengths that has passed through the arterial blood vessel of said subject; (d) determining the pulsatile changes in absorbance of the two wavelengths of light by the subject'"'"'s arterial blood; (e) determining the ratio of change in absorbance of the two wavelengths, and; (f) calculating the concentration of carboxyhemoalobin in said subject'"'"'s blood by comparing the ratio of change in absorbance of the two wavelengths to ratios measured in subjects with known carboxyhemoglobin levels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A device for the non-invasive measurement of the concentration of carboxyhemoglobin in a subject'"'"'s blood, wherein the reduced hemoglobin constituent of said subject'"'"'s blood has been converted to oxyhemoglobin by having the subject breathe supplemental oxygen, said device comprising:
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a clamp for holding a portion of the tissue of the subject through which pulsatile flow of arterial blood can be detected; two LEDs mounted on said clamp, the first LED emitting light at a wavelength which is absorbed substantially equally by the oxy- and carboxyhemoglobin constituents of the subject'"'"'s blood, and the second LED emitting light at a wavelength which is absorbed differentially by the oxy- and carboxyhemoglobin constituents of the subject'"'"'s blood; at least one light detector mounted on said clamp for detecting the light emitted by the two LEDs after the light has passed through the tissue of the subject; means for transmitting the data from the light detector, and; means for calculating the concentration of carboxyhemoglobin in said subject'"'"'s blood by determining the pulsatile changes in absorbance of the two wavelengths of light by the subject'"'"'s arterial blood and comparing the ratio of the pulsatile changes in absorbance to ratios measured in subjects with known carboxyhemoglobin levels, said means for calculating including a means for receiving data from the light detector. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification