Methods and apparatus for classifying cardiac events with an implantable cardiac device

• US 5,810,739 A
• Filed: 12/19/1996
• Issued: 09/22/1998
• Est. Priority Date: 05/09/1996
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Kleks, Jonathan A., Bornzin, Gene A., Vogel, Alan B., Zadeh, Ali Enayat, Wilson, Raymond J.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US08/770,767
• Time in Patent Office: 642 Days
• Field of Search: 128/696, 128/697, 128/699
• US Class Current: 600/510
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

Methods and apparatus are provided for classifying cardiac events with an implantable cardiac device. Cardiac signals are stored in a buffer. When a significant cardiac event is confirmed, a corresponding segment of the stored cardiac signals is processed to generate a set of feature values. The set of feature values is compared to various sets of reference values. Each set of reference values preferably corresponds to a separate type of cardiac event, so that the cardiac device may classify the significant cardiac event by matching its set of feature values to a set of reference values. Feature values include the maximum positive and negative slew rates exhibited by the cardiac signal during the segment, the maximum positive and negative signal amplitudes, the times to reach the maximum positive and negative signal amplitudes, the area under the cardiac signal curve, the area under the cardiac signal curve above zero as compared to the area below zero, and the number of zero crossings made by the cardiac signal. Additional feature values are generated by simultaneously processing the cardiac signals measured along two different vector directions in the heart.

Claims

1. An implantable cardiac device for monitoring a cardiac signal from a patient'"'"'s heart via leads connected to said heart, processing a segment of said cardiac signal that corresponds to a cardiac event, and classifying said cardiac event as being one of a plurality of possible types of cardiac events, each such possible type of cardiac event being characterized by a separate set of reference values, the implantable cardiac device comprising:

sensing circuitry connected to said leads for measuring said cardiac signals;

buffer means for storing said cardiac signals;

means for generating a set of feature values for said cardiac signal segment; and

means for classifying said cardiac event by comparing said set of feature values to said sets of reference values to determine the closest match to said set of feature values from among said sets of reference values.

2. The implantable cardiac device of claim 1 further comprising means for confirming that said cardiac event has occurred.

3. The implantable cardiac device of claim 2 further comprising a threshold detector for detecting when said cardiac signals exceed a predetermined threshold.

4. The implantable cardiac device of claim 2 further comprising multiplexer means for selectively interconnecting said leads and said sensing circuitry.

5. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating a maximum positive amplitude feature value for said cardiac signal segment.

6. The implantable cardiac device of claim 5 wherein said means for generating said set of feature values further comprises means for generating a time to reach said maximum positive signal amplitude feature value for said cardiac signal segment.

7. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating a maximum negative amplitude feature value for said cardiac signal segment.

8. The implantable cardiac device of claim 7 wherein said means for generating said set of feature values further comprises means for generating a time to reach said maximum negative signal amplitude feature value for said cardiac signal segment.

9. The implantable cardiac device of claim 1 further comprising means for updating said reference values.

10. The implantable cardiac device of claim 1 wherein said buffer means comprises a circular buffer.

11. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating feature values selected from the group consisting of:

maximum positive and negative slew rates exhibited by said cardiac signal segment, maximum positive and negative signal amplitudes exhibited by said cardiac signal segment, times to reach said maximum positive and negative signal amplitudes, area under said cardiac signal segment, area under said cardiac signal segment above zero as compared to area under said cardiac signal segment below zero, and number of zero crossings made by said cardiac signal segment.

12. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating a maximum positive slew rate feature value for said cardiac signal segment.

13. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating a maximum negative slew rate feature value for said cardiac signal segment.

14. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating an area under said cardiac signal segment feature value for said cardiac signal segment.

15. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating an area under said cardiac signal segment above zero as compared to area under said cardiac signal segment below zero feature value for said cardiac signal segment.

16. The implantable cardiac device of claim 1 wherein said means for generating said set of feature values comprises means for generating a number of zero crossings feature value for said cardiac signal segment.

17. The implantable cardiac device of claim 1 wherein:

said sensing circuitry comprises means for simultaneously measuring cardiac signals with a first pair of electrodes along a first vector in said heart and a second pair of electrodes along a second vector in said heart; and

said means for generating said set of feature values comprises means for comparing said cardiac signals measured along said first vector with said cardiac signals measured along said second vector.

18. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate feature values selected from the group consisting of:

initial quadrant, confirmation quadrant, terminal quadrant, clockwise/counterclockwise rotation, initial trajectory, confirmation trajectory, terminal trajectory, comparative maximum slew rate, comparative maximum amplitude, comparative area under said cardiac signal segment, and comparative number of zero crossings.

19. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate an initial quadrant feature value for said cardiac signal segment.

20. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a confirmation quadrant feature value for said cardiac signal segment.

21. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a terminal quadrant feature value for said cardiac signal segment.

22. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a clockwise/counterclockwise rotation feature value for said cardiac signal segment.

23. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate an initial trajectory feature value for said cardiac signal segment.

24. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a confirmation trajectory feature value for said cardiac signal segment.

25. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a terminal trajectory feature value for said cardiac signal segment.

26. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a comparative maximum slew rate feature value for said cardiac signal segment.

27. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a comparative maximum amplitude feature value for said cardiac signal segment.

28. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a comparative area under said cardiac signal segment feature value for said cardiac signal segment.

29. The implantable cardiac device of claim 17 wherein said means for comparing comprises means for comparing said cardiac signals measured along said first and second vectors to generate a comparative number of zero crossings feature value for said cardiac signal segment.

30. A method for monitoring cardiac signals from a patient'"'"'s heart with an implantable cardiac device having sensing circuitry connected to said heart via leads for receiving said cardiac signals and having a buffer in which a cardiac signal segment that corresponds to a cardiac event is stored, the method including the classification of said cardiac event as being one of a plurality of possible types of cardiac events, each such possible type of cardiac event being characterized by a separate set of reference values, the method comprising the steps of:

measuring said cardiac signals with said sensing circuitry;

storing said cardiac signals in said buffer;

generating a set of feature values for said cardiac signal segment; and

classifying said cardiac event by comparing said set of feature values to each of said sets of reference values to determine the closest match to said set of feature values from among said sets of reference values.

31. The method of claim 30 further comprising the step of confirming that said cardiac event has occurred.

32. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating feature values selected from the group consisting of:

maximum positive and negative slew rates exhibited by said cardiac signal segment, maximum positive and negative signal amplitudes exhibited by said cardiac signal segment, times to reach said maximum positive and negative signal amplitudes, area under said cardiac signal segment, area under said cardiac signal segment above zero as compared to area under said cardiac signal segment below zero, and number of zero crossings made by said cardiac signal segment.

33. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating a maximum positive slew rate feature value for said cardiac signal segment.

34. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating a maximum negative slew rate feature value for said cardiac signal segment.

35. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating a maximum positive amplitude feature value for said cardiac signal segment.

36. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating a time to reach said maximum positive signal amplitude feature value for said cardiac signal segment.

37. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating a maximum negative amplitude feature value for said cardiac signal segment.

38. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating a time to reach said maximum negative signal amplitude feature value for said cardiac signal segment.

39. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating an area under said cardiac signal segment feature value for said cardiac signal segment.

40. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating an area under said cardiac signal segment above zero as compared to area under said cardiac signal segment below zero feature value for said cardiac signal segment.

41. The method of claim 30 wherein said step of generating said set of feature values comprises the step of generating a number of zero crossings feature value for said cardiac signal segment.

42. The method of claim 30 further comprising the step of updating said reference values.

43. The method of claim 30 wherein said step of storing said cardiac signals in said buffer comprises the step of storing said cardiac signals in a circular buffer.

44. The method of claim 30 further comprising the step of detecting when said cardiac signals exceed a predetermined threshold.

45. The method of claim 30 further comprising the step of selectively interconnecting said leads and said sensing circuitry with multiplexer circuitry.

46. The method of claim 30 further comprising the steps of:

using said sensing circuitry to simultaneously measure cardiac signals with a first pair of electrodes along a first vector in said heart and with a second pair of electrodes along a second vector in said heart; and

comparing said cardiac signals measured along said first vector with said cardiac signals measured along said second vector to generate said set of feature values.

47. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate feature values selected from the group consisting of:

initial quadrant, confirmation quadrant, terminal quadrant, clockwise/counterclockwise rotation, initial trajectory, confirmation trajectory, terminal trajectory, comparative maximum slew rate, comparative maximum amplitude, comparative area under said cardiac signal segment, and comparative number of zero crossings.

48. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate an initial quadrant feature value for said cardiac signal segment.

49. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a confirmation quadrant feature value for said cardiac signal segment.

50. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a terminal quadrant feature value for said cardiac signal segment.

51. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a clockwise/counterclockwise rotation feature value for said cardiac signal segment.

52. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate an initial trajectory feature value for said cardiac signal segment.

53. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a confirmation trajectory feature value for said cardiac signal segment.

54. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a terminal trajectory feature value for said cardiac signal segment.

55. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a comparative maximum slew rate feature value for said cardiac signal segment.

56. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a comparative maximum amplitude feature value for said cardiac signal segment.

57. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a comparative area under said cardiac signal segment feature value for said cardiac signal segment.

58. The method of claim 46 wherein said step of comparing comprises the step of comparing said cardiac signals measured along said first and second vectors to generate a comparative number of zero crossings feature value for said cardiac signal segment.

59. An implantable cardiac device for monitoring a cardiac signal from a patient'"'"'s heart via leads connected to said heart, processing a segment of said cardiac signal that corresponds to a cardiac event, and classifying said cardiac event as being one of a plurality of possible types of cardiac events, each such possible type of cardiac event being characterized by a separate set of reference values, the implantable cardiac device comprising:

sensing circuitry, connected to said leads, for simultaneously measuring cardiac signals with a first pair of electrodes along a first vector in said heart and a second pair of electrodes along a second vector in said heart;

buffer means for storing said cardiac signals;

means for generating a set of feature values for said cardiac signal segment, said means for generating comprising means for comparing said cardiac signals measured along said first vector with said cardiac signals measured along said second vector; and

means for classifying said cardiac event by comparing said set of feature values to said sets of reference values to determine the closest match to said set of feature values from among said sets of reference values.

60. A method for monitoring cardiac signals from a patient'"'"'s heart with an implantable cardiac device having sensing circuitry connected to said heart via leads for receiving said cardiac signals and having a buffer in which a cardiac signal segment that corresponds to a cardiac event is stored, the method including the classification of said cardiac event as being one of a plurality of possible types of cardiac events, each such possible type of cardiac event being characterized by a separate set of reference values, the method comprising the steps of:

using said sensing circuitry to simultaneously measure cardiac signals with a first pair of electrodes along a first vector in said heart and with a second pair of electrodes along a second vector in said heart;

storing said cardiac signals in said buffer;

generating a set of feature values for said cardiac signal segment by comparing said cardiac signals measured along said first vector with said cardiac signals measured along said second vector; and

classifying said cardiac event by comparing said set of feature values to each of said sets of reference values to determine the closest match to said set of feature values from among said sets of reference values.

61. An implantable cardiac device for monitoring a cardiac signal from a patient'"'"'s heart via leads connected to said heart, processing a segment of said cardiac signal that corresponds to a cardiac event, and classifying said cardiac event as being one of a plurality of possible types of cardiac events, each such possible type of cardiac event being characterized by a separate set of reference values, the implantable cardiac device comprising:

sensing circuitry connected to said leads for measuring said cardiac signals;

buffer means for storing said cardiac signals;

means for generating a set of feature values for said cardiac signal segment, wherein the feature values are selected from the group consisting of;

a maximum positive slew rate, a maximum negative slew rate, a maximum positive signal amplitude, a maximum negative signal amplitude, a time to reach a maximum positive signal amplitude, a time to reach a maximum negative signal amplitude, an area under said cardiac signal segment, an area under said cardiac signal segment above zero as compared to an area under said cardiac signal segment below zero, and a number of zero crossings made by said cardiac signal segment; and

means for classifying said cardiac event by comparing said set of feature values to said sets of reference values to determine the closest match to said set of feature values from among said sets of reference values.

62. The implantable cardiac device of claim 61, further comprising means for updating said reference values.

63. The implantable cardiac device of any of claims 61-62 wherein said buffer means comprises a circular buffer.

64. A method for monitoring cardiac signals from a patient'"'"'s heart with an implantable cardiac device having sensing circuitry connected to said heart via leads for receiving said cardiac signals and having a buffer in which a cardiac signal segment that corresponds to a cardiac event is stored, the method including the classification of said cardiac event as being one of a plurality of possible types of cardiac events, each such possible type of cardiac event being characterized by a separate set of reference values, the method comprising the steps of:

measuring said cardiac signals with said sensing circuitry;

storing said cardiac signals in said buffer;

generating a set of feature values for said cardiac signal segment selected from the group of feature values consisting of;

a maximum positive slew rate, a maximum negative slew rate, a maximum positive signal amplitude, a maximum negative signal amplitude, a time to reach a maximum positive signal amplitude, a time to reach a maximum negative signal amplitude, an area under said cardiac signal segment, an area under said cardiac signal segment above zero as compared to an area under said cardiac signal segment below zero, and a number of zero crossings made by said cardiac signal segment; and

classifying said cardiac event by comparing said set of feature values to each of said sets of reference values to determine the closest match to said set of feature values from among said sets of reference values.