Instrument for collecting multiple biopsy specimens

• US 5,810,744 A
• Filed: 11/18/1997
• Issued: 09/22/1998
• Est. Priority Date: 05/17/1993
• Status: Expired due to Term

• Current Assignee: Boston Scientific Corporation
• Original Assignee: Boston Scientific Corporation
• Inventors: Chin, Yem, Chu, Michael S.H.
• Primary Examiner(s): Hindenburg, Max
• Application Number:
  US08/972,174
• Time in Patent Office: 308 Days
• Field of Search: 600/562, 600/564-567, 606/167, 606/170
• US Class Current: 600/567
• CPC Class Codes: A61B 10/0275 with sample notch, e.g. on the side of inner stylet
• CPC Class Codes: A61B 10/04 Endoscopic instruments
• CPC Class Codes: A61B 2010/0225 for taking multiple samples

Abstract

The invention features a medical biopsy instrument including a relatively long shaft having proximal and distal ends, a biopsy assembly, located at the distal end of the shaft, an actuator located at the proximal end of the shaft, and a force-transmitting member associated with the shaft and extending from the actuator to the biopsy assembly. The biopsy assembly is constructed to receive tissue in a biopsy space and store severed tissue in a storage space. When collecting biopsy specimens, the biopsy assembly severs tissue located in the biopsy space and thereafter stores the severed tissue in the storage space. The storage space is arranged to store sequentially multiple severed biopsy specimens taken by multiple repeated actuations of the biopsy assembly. The biopsy assembly has a side cutting or a forward cutting embodiment and may be mounted of a catheter.

Claims

1. A forward-sampling instrument for obtaining multiple tissue samples from tissue sites within a body, comprising:

a proximal portion that remains outside the body including an actuator with a force transmitting element extending from said actuator,

a flexible, elongated catheter body portion constructed to follow a path to said tissue sites within the body, said force transmitting element extending through an interior of said catheter body portion, and

a distal portion defining a central axis and including a storage space in which multiple biopsy samples are stored, said storage space located proximal to a forward-sampling cutter, said cutter having relatively moveable cutting elements constructed to receive tissue and sever samples from tissue sites in front of said cutter, said moveable cutting elements including a cutting element connected to said force-transmitting element, distally extendable at an angle transverse to the axis defined by the distal portion, and terminating in a cutting edge, said cutter being controlled with said actuator at said proximal portion by applying forces to said force-transmitting element so that movement of the cutting element in a proximal direction relative to the catheter body portion causes the cutting element to sever a tissue sample and move the tissue sample into the storage space, and said storage space being adjacent and proximal to said cutter for storing a succession of samples while further samples are severed by said cutter.

2. The instrument of claim 1 wherein said force transmitting element is a wire.

3. The instrument of claim 1 wherein said cutter includes a second cutting element extending parallel to said axis defined by the distal portion.

4. The instrument of claim 3 wherein said second cutting element is a tube.

5. The instrument of claim 4 wherein said cutting element extendable at an angle can be moved into and out of said tube.

6. The instrument of claim 5 wherein said cutting element extendable at an angle assumes a pre-shaped bend when moved out of said tube.

7. The instrument of claim 1 sized and constructed to pass through the working channel of an endoscope.

8. The instrument of claim 1 wherein the diameter of said storage space is sized to substantially correspond to the diameter of said samples.

9. The instrument of claim 1 wherein the angle of extension of said cutting member is constructed to control the size of said samples.

10. The instrument of claim 1 wherein said distal portion is constructed to permit retrieval of said samples from said storage space by extending said cutting element distally.

11. A method for obtaining multiple tissue samples from tissue sites within a body, comprising the steps of:

providing a forward-sampling instrument having

a proximal portion that remains outside the body including an actuator with a force transmitting element extending from said actuator,

a flexible, elongated catheter-body portion constructed to follow a path to said tissue sites within the body, said force transmitting element extending through an interior of said catheter-body portion, and

a distal portion defining a central axis including a storage space in which multiple biopsy samples are stored, said storage space located proximal to a forward-sampling cutter, said cutter having relatively moveable cutting elements constructed to receive tissue and sever samples from tissue sites in front of said cutter, said moveable cutting elements including a cutting element connected to said force-transmitting element, distally extendable at an angle transverse to the axis defined by the distal portion, and terminating in a cutting edge, said cutter being controlled with said actuator at said proximal portion by applying forces to said force-transmitting element, and said storage space being adjacent and proximal to said cutter for storing a succession of samples while further samples are severed by said cutter;

maneuvering said forward-sampling instrument along said path to a tissue site in front of said cutter;

extending said cutting element at an angle transverse to the axis defined by the distal portion by applying forces to said actuator which is transmitted by said force transmitting element extending through said catheter body to said cutter;

moving the cutting element in a proximal direction relative to the catheter-body portion so that the cutting element severs a tissue sample from the tissue site and moves the tissue sample into the storage space by applying forces to said actuator which are transmitted by said force-transmitting element extending through said catheter body to said cutter,

storing said sample in said storage space without removing said device from the body,

repeating said maneuvering, severing, and storing steps, and

removing said instrument from the body.

12. The method of claim 11 comprising removing said samples from said storage space by extending said cutting element distally to gain access to said storage space.

13. The method of claims 11 and 12 comprising:

passing said instrument along a path defined by the working channel of an endoscope.

14. The method of claim 11 wherein said force transmitting element is a wire.

15. The method of claim 11 wherein said cutter includes a second cutting element extending parallel to said axis defined by the distal portion.

16. The method of claim 15 wherein said second cutting element is a tube.

17. The method of claim 16 wherein said cutting element extendable at an angle can be moved into and out of said tube.

18. The method of claim 17 wherein said cutting element extendable at an angle assumes a pre-shaped bend when moved out of said tube.

19. The method of claim 11 wherein the diameter of said storage space is sized to substantially correspond to the diameter of said samples.

20. The method of claim 11 wherein the angle of extension of said cutting member is constructed to control the size of said samples.