Method and apparatus for pressurized intraluminal drug delivery
First Claim
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1. A method for intramural fluid delivery, said method comprising:
- expanding a balloon within a body lumen, said balloon having an outer peripheral surface;
providing a plurality of isolated fluid reservoir pockets between the outer peripheral surface of the balloon and an inner wall portion of the body lumen; and
delivering fluid to said isolated pockets, wherein at least some of the individual reservoir pockets are surrounded by a continuous periphery of the infusion tubes which deliver fluid to the pockets.
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Abstract
An intravascular catheter provides fluid infusion tubes over a balloon surface to form isolated reservoir pockets for delivering drugs intraluminally. The fluid infusion tubes will be arranged in a network which, upon balloon expansion, defines the isolated reservoir pockets between adjacent tubes. In one embodiment, the drug infusion tubes are formed as part of an expansible sleeve which is positioned over a separate balloon catheter for expansion. In another embodiment, the infusion tubes are disposed over a balloon of a balloon catheter.
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Citations
37 Claims
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1. A method for intramural fluid delivery, said method comprising:
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expanding a balloon within a body lumen, said balloon having an outer peripheral surface; providing a plurality of isolated fluid reservoir pockets between the outer peripheral surface of the balloon and an inner wall portion of the body lumen; and delivering fluid to said isolated pockets, wherein at least some of the individual reservoir pockets are surrounded by a continuous periphery of the infusion tubes which deliver fluid to the pockets. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An infusion catheter for intramural drug delivery within a body lumen, said infusion catheter comprising:
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a catheter body having a proximal end, a distal end, and a fluid delivery lumen therethrough; and a radially expansible segment disposed at the distal end of the catheter body, said radially expansible segment having a network of fluid infusion tubes which are arranged to form a plurality of isolated pockets when said segment is expanded against a body lumen wall, said fluid infusion tubes having infusion ports for delivering fluids into said isolated pockets, wherein at least some of said isolated pockets are surrounded by a continuous periphery of infusion tubes when said pockets are disposed against a lumenal wall. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. An infusion catheter for use in combination with a balloon catheter, said infusion catheter comprising:
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a catheter body having a proximal and a distal end; a radially expansible sleeve disposed at the distal end of the catheter body, said radially expansible sleeve having a central receptacle, for receiving a balloon or the balloon catheter, and a network of fluid infusion tubes which are arranged to form a plurality of isolated pockets when expanded by the balloon present in the central receptacle, said fluid infusion tubes having infusion ports for delivering fluids into said isolated pockets, wherein at least some of said isolated pockets are surrounded by a continuous periphery of infusion tubes when said pockets are disposed against a lumenal wall. - View Dependent Claims (27, 28, 29, 30, 31)
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32. An infusion catheter for use in combination with a balloon catheter, said infusion catheter comprising:
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a shaft having a proximal and a distal end and a fluid delivery lumen therethrough; a radially expansible sleeve disposed at the distal end of the shaft, said radially expansible sleeve having a (i) central receptacle for receiving a balloon or the balloon catheter and (ii a network of fluid infusion tubes which are arranged to form a plurality of isolated pockets when the sleeve is expanded by the balloon present in the central receptacle, said fluid infusion tubes having infusion ports for delivering fluids into said isolated pockets; and a manifold structure disposed between the shaft and the network of infusion tubes which distributes fluid from the fluid delivery lumen to the fluid infusion tubes. - View Dependent Claims (33, 34, 35, 36, 37)
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Specification