Binding assay and assay reagent
First Claim
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1. A metal-labeled binding partner comprising a binding partner covalently bonded to a luminescent iridium complex, wherein said iridum complex is Ir(bipy)2 (4'"'"'- 1,10-phenanthroline)!-phenoxy-acetic acid)3+.
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Abstract
A time-resolving luminescence binding assay involves a metal-labelled binding partner comprising a luminescent transition metal complex covalently attached to a binding partner such as an antigen or antibody. Ruthenim, iridium, osmium, and chromium luminescent complexes are described.
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Citations
5 Claims
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1. A metal-labeled binding partner comprising a binding partner covalently bonded to a luminescent iridium complex, wherein said iridum complex is Ir(bipy)2 (4'"'"'- 1,10-phenanthroline)!-phenoxy-acetic acid)3+.
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2. A metal-labeled binding partner comprising a binding partner covalently bonded to a luminescent iridium complex, wherein said iridium complex is Ir(bipy)2 (4"-carboxybenzyl-4'"'"'- 4(1,10-phenanthroline)!-phenyl ether3+.
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3. A metal-labeled binding partner comprising a binding partner covalently bonded to a luminescent iridium complex, wherein iridium complex is Ir(bipy)2 (4,7-diphenyl-1,10-phenanthroline)3+.
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4. A metal-labeled binding partner comprising a binding partner covalently bonded to a luminescent iridium complex, wherein said iridium complex is Ir(bipy)2 (2,2'"'"'-biquinoline)3+.
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5. A metal-labeled binding partner comprising a binding partner covalently bonded to a luminescent iridium complex, wherein said iridium complex is Ir(phen)2 (4'"'"'- 4-(1,10,10-phenanthroline)!-phenoxy-acetic acid)3+.
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Current AssigneeLonza Group AG
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Original AssigneeAlusuisse Holdings AG
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InventorsDavidson, Robert Stephen
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Primary Examiner(s)Green, Lora M.
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Application NumberUS08/447,847Time in Patent Office1,218 DaysField of Search435/7.1, 436/518, 436/526, 436/537, 436/543, 436/546, 436/164, 436/172, 436/800, 436/805, 530/345, 530/391.3, 530/391.5, 530/402, 532/136, 546/2, 546/10US Class Current530/391.3CPC Class CodesC09K 11/06 containing organic luminesc...G01N 33/533 with fluorescent labelG01N 33/553 Metal or metal coatedG01N 33/582 with fluorescent labelY10S 436/80 Fluorescent dyes, e.g. rhod...Y10S 436/805 Optical property
