Radiation measuring catheter apparatus and method

• US 5,811,814 A
• Filed: 02/12/1996
• Issued: 09/22/1998
• Est. Priority Date: 02/12/1996
• Status: Expired due to Term

• Current Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Leone, James E., Rowland, Stephen M.
• Primary Examiner(s): Glick, Edward J.
• Application Number:
  US08/599,824
• Time in Patent Office: 953 Days
• Field of Search: 250/368, 250/369, 128/656, 128/657, 128/658, 128/659
• US Class Current: 250/368
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00

Abstract

An apparatus for measuring radiation at a region of interest inside a body is disclosed. The apparatus comprises a fiber optic equipped-catheter having a distal portion adapted to be inserted in a blood vessel. The apparatus further includes a luminescent scintillation material coupled to the fiber optic light pipe. The scintillation material is disposed in a distal portion of a lumen of the catheter and generates pulses of electromagnetic radiation in response to excitation by radiation rays. The apparatus further includes an index matching material disposed between the scintillation crystal and the fiber optic light pipe facilitating transmission of the pulses of electromagnetic radiation produced by the scintillation material to the fiber optic light pipe. A measuring assembly is coupled to the fiber optic light pipe to convert the pulses of radiation traversing the fiber optic light pipe to a measure of radiation in the region of interest. A method of measuring radiation using the radiation measuring apparatus of the present invention is also disclosed. The steps of the method comprise: providing a catheter having a fiber optic light pipe coupled to a scintillation material supported by a distal portion of the catheter; inserting the distal portion of the catheter through an opening in the body; maneuvering the catheter to position the distal portion of the catheter within the region of interest; and converting the pulses of electromagnetic radiation transmitted along the fiber optic light pipe into a measure of radiation.

Claims

1. An apparatus for measuring radiation at a region of interest inside a body, the apparatus comprising:

a) a catheter adapted to be inserted into a blood vessel, a length of the catheter sufficient to extend to the region of interest while a proximal end of the catheter remains outside the body;

b) a scintillation material supported by a distal portion of the catheter, the scintillation material generating pulses of radiation in response to being struck by rays of radiation, the scintillation material having proximal and distal ends spaced apart along a catheter extent;

c) a fiber optic light pipe attached to the catheter and coupled to the scintillation material for receiving pulses of radiation generated by the scintillation material and transmitting the pulses along a length of the light pipe, the fiber optic light pipe extending from the scintillation material to a region outside the body;

d) a radiation measuring assembly coupled to a portion of the fiber optic light pipe in the region outside the body for converting the pulses of radiation transmitted along the length of the fiber optic light pipe to a measure of radiation at the region of interest; and

e) a first radiation blocking member positioned adjacent one of the proximal and distal ends of the scintillation material.

2. The apparatus for measuring radiation set forth in claim 1 wherein the catheter includes a lumen that extends through a portion of the catheter and wherein the scintillation material and a portion of the fiber optic light pipe are disposed in the lumen.

3. The apparatus for measuring radiation set forth in claim 1 wherein an index matching material is disposed between the scintillation material and an end of the fiber optic light pipe coupled to the scintillation material to facilitate receipt of the pulses of radiation by the fiber optic light pipe.

4. The apparatus for measuring radiation set forth in claim 1 additionally comprising a second radiation blocking member positioned adjacent an other of the distal and proximal ends of the scintillation material not bordered by said first radiation blocking member.

5. The apparatus for measuring radiation set forth in claim 1 wherein the scintillation material is a scintillation crystal comprising sodium iodide doped with thallium.

6. The apparatus for measuring radiation set forth in claim 1 wherein the catheter includes a guide member near a distal end of the catheter, the guide member including an aperture sized to slidingly overlie a guidewire such that the catheter may be routed along the guidewire to the region of interest.

7. The apparatus for measuring radiation set forth in claim 1 wherein the radiation measuring assembly includes a photodetector tube coupled to a proximal end of the fiber optic light pipe for converting the pulses of radiation traversing the light pipe into electric signals.

8. The apparatus for measuring radiation set forth in claim 7, wherein the radiation measuring assembly additionally includes a signal processor analyzer coupled to an output of the photodetector tube for converting the electric signals generated by the photodetector tube into the measure of radiation.

9. The radiation detection apparatus set forth in claim 1 wherein the scintillation material is a scintillation crystal comprising cesium iodide doped with thallium.

10. An apparatus for measuring radiation at a region of interest inside a body, the apparatus comprising:

a) a catheter adapted to be inserted into a blood vessel, a length of the catheter sufficient to extend to the region of interest while a proximal end of the catheter remains outside the body;

b) a scintillation material supported by a distal portion of the catheter, the scintillation material being a scintillation crystal consisting of sodium iodide doped with thallium and generating pulses of radiation in response to being struck by rays of radiation and wherein the scintillation crystal is generally cylindrical in shape having two end walls spaced apart by a side wall and further wherein a radiation blocking member is positioned adjacent one of the end walls;

c) a fiber optic light pipe attached to the catheter and coupled to the scintillation material for receiving pulses of radiation generated by the scintillation material and transmitting the pulses along a length of the light pipe, the fiber optic light pipe extending from the scintillation material to a region outside the body; and

d) a radiation measuring assembly coupled to a portion of the fiber optic light pipe in the region outside the body for converting the pulses of radiation transmitted along the length of the fiber optic light pipe to a measure of radiation at the region of interest.

11. An apparatus for measuring radiation at a region of interest inside a body, the apparatus comprising:

a) a catheter adapted to be inserted into a blood vessel, a length of the catheter sufficient to extend to the region of interest while a proximal end of the catheter remains outside the body, the catheter being doped with light reflective particles;

b) a scintillation material supported by a distal portion of the catheter, the scintillation material generating pulses of radiation in response to being struck by rays of radiation;

c) a fiber optic light pipe attached to the catheter and coupled to the scintillation material for receiving pulses of radiation generated by the scintillation material and transmitting the pulses along a length of the light pipe, the fiber optic light pipe extending from the scintillation material to a region outside the body; and

d) a radiation measuring assembly coupled to a portion of the fiber optic light pipe in the region outside the body for converting the pulses of radiation transmitted along the length of the fiber optic light pipe to a measure of radiation at the region of interest.

12. The apparatus for measuring radiation set forth in claim 11 wherein the catheter includes a lumen in which the fiber optic light pipe is disposed and a portion of the catheter adjacent the fiber optic light pipe is doped with light reflective particles.

13. A radiation detection apparatus comprising:

a) a catheter having a lumen supporting a fiber optic light pipe, the catheter adapted to be inserted into a body and having a length sufficient to permit a proximal end of the catheter to remain outside the body while a distal portion of the catheter is maneuvered within the body to a region of interest where radiation is sought to be detected and wherein at least a portion of a wall of the catheter is doped with a highly light reflective material;

b) a scintillation material disposed in the distal portion of the catheter and optically coupled to the fiber optic light pipe of the catheter, the scintillation material energized when stuck by photons emitted by a source of radiation to generate pulses of electromagnetic radiation which are transmitted to and traverse the fiber optic light pipe; and

c) a radiation measuring assembly optically coupled to the fiber optic light pipe for sensing and converting the pulses of electromagnetic radiation traversing the fiber optic light pipe into a measure of radiation at the region of interest.

14. The radiation detection apparatus set forth in claim 13 wherein the light reflective material is comprised of TiO₂.