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Optical measurement of tissue pH

  • US 5,813,403 A
  • Filed: 11/08/1995
  • Issued: 09/29/1998
  • Est. Priority Date: 11/08/1995
  • Status: Expired due to Term
First Claim
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1. A non-invasive method for determining the localized pH of a sample tissue disposed underneath a covering tissue of a patient, said method comprising:

  • irradiating the sample tissue with optical radiation not substantially absorbed by the covering tissue such that the radiation propagates through the covering tissue to irradiate the sample tissue;

    collecting radiation from the sample tissue which passes through the covering tissue to determine an optical spectrum; and

    ,processing the optical spectrum and a mathematical model to determine the localized pH of the sample tissue, said model relating optical spectra to known pH values of interstitial fluid in tissue.

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