Method and apparatus for applying tissue sealant

• US 5,814,022 A
• Filed: 02/06/1996
• Issued: 09/29/1998
• Est. Priority Date: 02/06/1996
• Status: Expired due to Term

• Current Assignee: Plasmaseal LLC
• Original Assignee: Plasmaseal LLC
• Inventors: Dorian, Randel, Antanavich, Richard D.
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): Shai, Daphna
• Application Number:
  US08/595,936
• Time in Patent Office: 966 Days
• Field of Search: 604/82, 604/83, 604/181, 604/187, 604/191, 604/207, 604/208, 604/209, 604/210, 604/211, 604/227
• US Class Current: 604/191
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: B05C 17/00516 Shape or geometry of the outlet orifice or the outlet element

Abstract

A device and method for applying a fibrinogen-based tissue sealant to seamlessly connect human or animal tissues or organ parts, to seal wounds, stop bleeding and the like by mixing fibrin or fibrinogen with blood clot-promoting coagulation factors are disclosed. The device includes two cylindrical compartments for separately containing the separate fluid components of the sealant preparation, which are simultaneously displaced from the respective compartments by means of plungers commonly depressable with the same effective strokes. The plungers may be depressed directly or by means of a common mechanism (e.g., rack and pinion) for accurately controlling the rate of dispensing fluid. The cylindrical compartments are of the same or different cross-sectional area and are arranged either concentrically or side-by-side. The device further includes a means for merging the two fluid components within an outer sleeve housing an inner needle. The sleeve and needle contain conduits for the flow of the two fluid sealant components as they are expressed from the respective compartments. Also disclosed are a convenient means of filling the two compartments, a means for mixing the fluid components, and for atomizing the effluent sealant fluid stream (i.e., spraying).

Claims

1. A dispenser comprising:

a plurality of separate parallel cylindrical compartments arranged concentrically, each of said cylindrical compartments having an outlet port at one end,

a number of plungers equal to said plurality of cylindrical compartments, and

a manifold having separate means for transporting fluid through the manifold from the outlet port of each cylindrical compartment to a common location on the surface of the manifold opposite said outlet ports.

2. The dispenser of claim 1, including means for actuating said plungers, wherein said means for actuating said plungers comprises a means for commonly actuating said plungers and a means for separately actuating said plungers.

3. The dispenser of claim 2, wherein said cylindrical compartments are coaxial, and said means for commonly actuating said plungers and said means for separately actuating said plungers comprise a coaxial inner plunger having a cap with a first diameter and a coaxial outer plunger having a coaxial cylindrical void into which said inner plunger is located, the diameter of said cap being greater than the diameter of said cylindrical void.

4. The dispenser of claim 2, wherein said means for commonly actuating said plungers comprises a rack and pinion mechanism.

5. The dispenser of claim 4, wherein each said plunger has a cap and said means for commonly actuating said plungers comprises means for mechanically connecting said pinion to the cap of each said plunger.

6. The dispenser of claim 1, wherein said cylindrical compartments comprise inner and outer concentric compartments, the inner concentric cylindrical compartment being fitted with an inner plunger, and the outer concentric compartment being fitted with a cylindrical plunger having a coaxial cylindrical void within which said inner plunger is located.

7. The dispenser of claim 1, wherein said plurality of cylinders is 2, said cylinders have equal heights, and the volume ratio of said cylinders is 10 or greater.

8. A dispenser comprising:

a plurality of separate parallel cylindrical compartments, arranged side-by-side, each of said cylindrical compartments having an outlet port at one end,

a number of plungers equal to said plurality of cylindrical compartments,

means for actuating said plungers, and

a manifold having separate means for transporting fluid through the manifold from the outlet port of each cylindrical compartment to a common location on the surface of the manifold opposite said outlet ports,

wherein said means for actuating said plungers comprises a rack and pinion mechanism for commonly actuating said plungers and means for separately actuating said plungers.

9. The dispenser of claim 8, wherein said plurality of cylinders is 2, said cylinders have equal heights, and the volume ratio of said cylinders is 10 or greater.

10. The dispenser of claim 8, wherein each said plunger has a cap and said means for commonly actuating said plungers comprises means for mechanically connecting said pinion to a cap of each said plunger.