Pacemaker and method of operating same that provides functional atrial cardiac pacing with ventricular support

• US 5,814,077 A
• Filed: 05/12/1997
• Issued: 09/29/1998
• Est. Priority Date: 11/13/1992
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated), General Motors Corporation (Motors Liquidation Co. GUC Trust)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Florio, Joseph J., Bornzin, Gene A., Levine, Paul A., Sholder, Jason A.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US08/854,797
• Time in Patent Office: 505 Days
• Field of Search: 607/9
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

A special type of AV/PV hysteresis is provided in a dual-chamber pacemaker. A long AV delay is initially provided, thereby affording as much opportunity as possible for natural AV conduction to occur. Such long AV delay is automatically shortened should AV block occur. Periodic scanning for the return of AV conduction (absence of AV block) is performed so that the AV delay can be returned to its long value as soon as possible. In one embodiment, the pacemaker "learns" the natural conduction time (AR interval) of the patient and thereafter uses such learned natural conduction time as a reference against which subsequently measured AR intervals are compared to better distinguish conducted ventricular contractions from ectopic, pathologic, or other nonconducted ventricular contractions (e.g., PVC'"'"'s). If the measured AR interval is approximately the same as the "learned" AR interval, then the R-wave at the conclusion of the measured AR interval is presumed to be a conducted R-wave that signals the return of AV conduction, and the AV delay is lengthened back to its original value. If, on the other hand, the measured AR interval is significantly different than the "learned" natural conduction time, then the R-wave at the conclusion of the measured AR interval is presumed to be a nonconducted R-wave, and the AV delay is kept short. In other embodiments, other techniques are used to distinguish a conducted R-wave from a nonconducted R-wave.

Claims

1. A method of controlling the operation of a dual-chamber electronic pacemaker, the pacemaker having pulse generating means for selectively generating an atrial stimulation pulse (A-pulse) and a ventricular stimulation pulse (V-pulse);

timing means for generating specified time intervals, including an AV interval;

sensing means for sensing selected cardiac events, including P-waves and R-waves;

means for controlling the pulse generating means as a function of whether the sensing means senses certain prescribed events during a given time interval generated by the timing means, the method comprising;

(a) measuring an AR interval defined as a time interval between an atrial event and a sensed R-wave, the atrial event comprising either the generation of an A-pulse or the sensing of a P-wave;

(b) averaging the AR interval over a prescribed number of cardiac cycles to define a "learned" AR interval, the "learned" AR interval corresponding to a natural conduction time of the heart;

(c) determining whether an R-wave is naturally conducted by comparing the AR interval of an R-wave which occurs during an original AV interval with the "learned" AR interval, the original AV interval comprising a time interval generated by the timing means that commences with an atrial event and terminates a prescribed period of time thereafter;

(d) shortening the AV interval by a specified amount to produce a short AV interval whenever AV conduction is determined not to be present; and

(e) returning the AV interval to the original AV interval whenever AV conduction has returned, and keeping the AV interval at its short value whenever AV conduction has not returned.

2. The method of claim 1, further comprising regularly checking, whenever the short AV interval is being used, to see if AV conduction has returned.

3. The method of claim 2, wherein the regularly checking step comprises scanning for an occurrence of an R-wave on a regular basis by:

(1) lengthening the short AV interval back to the original AV interval;

(2) sensing whether an R-wave occurs before the termination of the AV interval lengthened in step (1), and if so measuring an AR interval associated with such sensed R-wave; and

(3) comparing the measured AR interval of the R-wave sensed in the sensing step (2) with the "learned" AR interval to determine if such R-wave represents a return of AV conduction.

4. The method of claim 3, wherein:

step (1) comprises incrementally lengthening the AV interval back to the original AV interval in small increments over several cardiac cycles; and

step (2) comprises sensing whether an R-wave occurs before the termination of the incrementally lengthened AV interval of each cardiac cycle.

5. The method of claim 2, wherein the regularly checking step comprises scanning for an occurrence of an R-wave on a regular basis by:

(1) lengthening the short AV interval back to the original AV interval;

(2) starting a reference time interval upon an occurrence of an atrial event during each cardiac cycle, the reference time interval comprising an interval within a prescribed safety margin of the "learned" AR interval; and

(3) sensing whether an R-wave occurs after the termination of the reference time interval but before the termination of the original AV interval, and if so making a presumption that AV conduction has returned.

6. The method of claim 5, wherein step (2) comprises setting the reference time interval equal to the "learned" AR interval in addition to a prescribed safety margin.

7. The method of claim 6, wherein the prescribed safety margin comprises at least 25 ms.

8. The method of claim 5, wherein:

step (1) comprises incrementally lengthening the AV interval back to its original AV interval in small increments over several cardiac cycles;

step (2) comprises starting the reference time interval during each cardiac cycle; and

step (3) comprises sensing whether an R-wave occurs after the termination of the reference time interval but before the termination of the incrementally lengthened AV interval during each cardiac cycle, and if so making a presumption that AV conduction has returned, incrementally lengthened AV interval of each cardiac cycle.

9. The method of claim 8, wherein step (2) comprises making the reference time interval be equal to the "learned" AR interval within a prescribed safety margin.

10. The method of claim 7, wherein the prescribed safety margin comprises at least 25 ms.

11. The method of claim 1, wherein the regularly checking step comprises scanning for the occurrence of an R-wave every n cardiac cycles, where n comprises an integer of between 4 to 16 cardiac cycles.

12. The method of claim 11, further comprising increasing n to an integer of between 127 and 256 whenever an R-wave does not occur after a first scanning therefor.

13. The method of claim 11, wherein step (c) comprises detecting whether an R-wave occurs in a cardiac cycle (1) after an atrial event, and (2) before the original AV interval has terminated, and (3) after the short AV interval has terminated.

14. The method of claim 13, further comprising resuming that any R-wave detected after the atrial event and before the short AV interval has terminated is representative of a nonconducted R-wave.

15. The method of claim 1, wherein the electronic pacemaker further includes physiological sensing means for sensing a physiologic condition of a patient;

and means for defining a sensor-indicated rate (SIR), the SIR providing a measure of a minimum acceptable cardiac rate for a given sensed physiologic condition of the patient, the method further comprising;

adjusting the amount by which the original AV interval is shortened to produce the short AV interval as a function of the SIR.

16. The method of claim 15, further comprising adjusting the original AV interval as a function of the SIR.

17. A dual-chamber electronic pacemaker, comprising:

pulse generating means for selectively generating an atrial stimulation pulse (A-pulse) and a ventricular stimulation pulse (V-pulse);

timing means for generating specified time intervals, including an AV interval;

sensing means for sensing selected cardiac events, including P-waves and R-waves;

control means for controlling the pulse generating means as a function of whether the sensing means senses certain prescribed events during a given time interval generated by the timing means, the control means including;

means for measuring an AR interval defined as a time interval between an atrial event and a sensed R-wave, the atrial event comprising either a stimulation A-pulse or a sensed P-wave;

means for averaging the AR interval over a prescribed number of cardiac cycles to define a "learned" AR interval, the "learned" AR interval corresponding to a natural conduction time of the heart;

means for determining whether a sensed R-wave is a conducted R-wave by comparing the AR interval of an R-wave which occurs during an original AV interval with the "learned" AR interval, the original AV interval comprising a time interval generated by the timing means that commences with an atrial event and terminates a prescribed period of time thereafter;

means for shortening the AV interval by a specified amount to produce a short AV interval whenever AV conduction is determined not to be present; and

means for returning the AV interval to a long AV interval whenever AV conduction has returned, and for keeping the AV interval at its short value whenever AV conduction has not returned.

18. The pacemaker of claim 17, further comprising means for regularly checking, whenever the short AV interval is being used, to see if AV conduction has returned.

19. The pacemaker of claim 17, wherein the means for regularly checking to see if AV conduction has returned comprises scanning means for scanning for an occurrence of an R-wave, the scanning means comprising:

means for lengthening the short AV interval back to the original AV interval;

means for sensing whether an R-wave occurs before the termination of the lengthened AV interval, and if so, for measuring an AR interval associated with such sensed R-wave; and

means for comparing the measured AR interval associated with the sensed R-wave against the "learned" AR interval to determine if such R-wave represents a return of AV conduction.

20. The pacemaker of claim 19, wherein:

the scanning means comprises means for incrementally lengthening the AV interval back to its original AV interval in small increments over several cardiac cycles; and

the means for sensing whether an R-wave occurs comprises means for sensing whether an R-wave occurs before the termination of the incrementally lengthened AV interval of each cardiac cycle.