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Hydrophilic polystyrene graft copolymer vehicle for intravaginal administration of pharmacologically active agents

  • US 5,814,329 A
  • Filed: 11/12/1996
  • Issued: 09/29/1998
  • Est. Priority Date: 11/12/1996
  • Status: Expired due to Term
First Claim
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1. A sustained release vaginal dosage form comprising:

  • (A) a drug or a plurality of drugs to be delivered, and(B) a drug delivery vehicle consisting essentially of a thermoplastic graft copolymer, said graft copolymer being a reaction product of;

    (1) a polystyrene macromonomer having an ethylenically unsaturated functional group, and(2) at least one hydrophilic acidic monomer having an ethylenically unsaturated functional group;

    wherein the weight percent of the polystyrene macromonomer in the graft copolymer is between about 1 and about 20%, and the weight percent of the total hydrophilic monomer in the graft copolymer is between 80 and 99%, wherein at least about 10% of said total hydrophilic monomer is acidic, said graft copolymer when fully hydrated having an equilibrium water content of at least 90%,said graft copolymer being present in said dosage form in an amount sufficient to cause said dosage form to form a water swollen but insoluble jelly like mass upon contact with the biological environment.

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