Methods and compositions for optimization of oxygen transport by cell-free systems
First Claim
Patent Images
1. A blood product solution, comprising an oxygen-carrying component comprising polyethylene glycol-modified hemoglobin, and a non-oxygen carrying component comprising a colloid starch, said blood product solution having oncotic pressure higher than that of plasma and viscosity at least half that of blood.
2 Assignments
0 Petitions
Accused Products
Abstract
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of any hemoglobin-based oxygen carrier, while the non-oxygen carrying plasma expander my consist of an oncotic colloid-like starch.
131 Citations
27 Claims
- 1. A blood product solution, comprising an oxygen-carrying component comprising polyethylene glycol-modified hemoglobin, and a non-oxygen carrying component comprising a colloid starch, said blood product solution having oncotic pressure higher than that of plasma and viscosity at least half that of blood.
-
6. A blood product solution, comprising:
-
a) an oxygen-carrying component, said oxygen-carrying component comprising a polyethylene glycol-modified hemoglobin; and b) a non-oxygen carrying component, said non-oxygen-carrying component comprising a colloid starch having an average molecular weight of from approximately 200,000 daltons to approximately 400,000 daltons. - View Dependent Claims (7, 8, 9, 10, 11)
-
-
12. A blood product solution, comprising:
-
a) an oxygen-carrying component, said oxygen-carrying component comprising a polyethylene glycol-modified hemoglobin; and b) a non-oxygen carrying component, said non-oxygen carrying component comprising pentastarch. - View Dependent Claims (13, 14, 15)
-
-
16. A method of enhancing oxygen delivery to the tissues of a mammal, comprising:
-
a) providing a blood product solution, comprising an oxygen-carrying component comprising polyethylene glycol-modified hemoglobin and a non-oxygen carrying component comprising a colloid starch, said blood product solution having oncotic pressure higher than that of plasma and viscosity at least half that of blood; and b) administering said blood product solution to said mammal, thereby enhancing oxygen delivery to the tissues of said mammal. - View Dependent Claims (17, 18, 19, 20)
-
-
21. A method of enhancing oxygen delivery to the tissues of a mammal, comprising:
-
a) providing a blood product solution, comprising; i) an oxygen-carrying component, said oxygen-carrying component comprising a polyethylene glycol-modified hemoglobin, and ii) a non-oxygen carrying component, said non-oxygen carrying component comprising a colloid starch having an average molecular weight of from approximately 200,000 daltons to approximately 350,000 daltons, b) administering said blood product solution to said mammal, thereby enhancing oxygen delivery to the tissues of said mammal. - View Dependent Claims (22, 23, 24, 25, 26, 27)
-
Specification