Urogenous component measuring apparatus for qualitatively/quantitatively measuring a plurality of urogenous components

• US 5,815,260 A
• Filed: 10/17/1996
• Issued: 09/29/1998
• Est. Priority Date: 10/18/1995
• Status: Expired due to Fees

• Current Assignee: Kyoto Daiichi Kagaku Company Limited
• Original Assignee: Kyoto Daiichi Kagaku Company Limited
• Inventors: Matsuoka, Koji, Dou, Xiaoming, Uenoyama, Harumi, Wang, Yung Xiang
• Primary Examiner(s): McGraw, Vincent P.
• Application Number:
  US08/733,637
• Time in Patent Office: 712 Days
• Field of Search: 356/301
• US Class Current: 356/301
• CPC Class Codes: A61B 10/007 for taking urine samples measuring urological functions A61B5/20; genital receptacles A61F5/451; urinals for bed-ridden persons A61G9/006
• CPC Class Codes: G01N 21/65 Raman scattering

Abstract

A concave urine collector is set under a front end portion of a stool body, so that urine can be collected in a bowl. Single fiber holes are set on a front end and a left side of the urine collector respectively, while condenser lenses for condensing light on the bowl side, an excitation light fiber member carrying excitation light from an excitation light source and a Raman light receiving fiber member for receiving Raman light are set in the fiber holes respectively. The excitation light fiber member is connected with the excitation light source, and the Raman light receiving fiber member communicates with a spectro-detector. A Raman signal separated into its spectral components detected by the spectro-detector is data-processed by a data processing part, and outputted from a data output part as a measurement result.

Claims

1. A urogenous component measuring apparatus comprising:

a stool body;

a urine collector being provided in said stool body on a position for receiving urine;

an excitation light source part for generating excitation light of a visible or infrared wavelength region;

a measuring/photoreceiving part for irradiating a urine specimen in said urine collector with said excitation light from said excitation light source part and receiving target light including Raman light generated from said urine specimen being irradiated with said excitation light;

an optical system including a spectro-detector for incorporating said target light being received in said measuring/photoreceiving part and measuring either a Raman spectral intensity at a selected measuring shift wavenumber or a Raman spectral intensity at each shift wavenumber in an arbitrary shift wavenumber range as to a urogenous component to be measured;

a data processing part for incorporating said Raman spectral intensity measured value obtained in said optical system for calculating at least one urogenous component concentrations on the basis thereof; and

a data output part for outputting a data analysis result by said data processing part.

2. The urogenous component measuring apparatus in accordance with claim 1, wherein

said measuring shift wavenumber being selected for said urogenous component to be measured is a shift wavenumber being specific to said component having excellent correlation between a concentration and a Raman spectral intensity in aqueous solution measurement of said urogenous component, and

said data processing part holds calibration curve data indicating relations between concentrations and Raman spectral intensities at respective measuring shift wavenumbers as to a plurality of urogenous components, for incorporating Raman spectral intensity measured values at said respective measuring shift wavenumbers as to said plurality of urogenous components and simultaneously qualitatively/quantitatively analyzing said plurality of urogenous components through said calibration curve data.

3. The urogenous component measuring apparatus in accordance with claim 2, wherein

said measuring shift wavenumber is a shift wavenumber having a correlation coefficient R of at least 0.8 in aqueous solution measurement of said urogenous component.

4. The urogenous component measuring apparatus in accordance with claim 1, wherein

said measuring shift number being selected as to said urogenous component to be measured is a shift wavenumber being specific to said component having excellent correlation between a concentration and a Raman spectral intensity in aqueous solution measurement of said urogenous component, and

said data processing part incorporates Raman spectral intensity measured values at respective measuring shift wavenumbers as to a plurality of urogenous components and simultaneously qualitatively/quantitatively analyzes said plurality of urogenous components by multivariate regression analysis.

5. The urogenous component measuring apparatus in accordance with claim 4, wherein

said measuring shift wavenumber is a shift wavenumber having a correlation coefficient R of at least 0.8 in aqueous solution measurement of said urogenous component.

6. The urogenous component measuring apparatus in accordance with claim 1, wherein

said data processing part incorporates Raman spectral intensity measured values at respective wavelengths in an arbitrary wavelength range as to a plurality of urogenous components and simultaneously qualitatively/quantitatively analyzes said plurality of urogenous components by multivariate regression analysis.

7. The urogenous component measuring apparatus in accordance with claim 1, containing creatinine as said urogenous component to be measured, wherein said data processing part corrects other urogenous component concentrations with reference to a creatinine concentration.

8. The urogenous component measuring apparatus in accordance with claim 1, wherein

said spectro-detector comprises a multichannel photodetector for simultaneously detecting Raman spectral intensities at a plurality of shift wavenumbers.

9. The urogenous component measuring apparatus in accordance with claim 1, wherein

a scupper is provided on a base portion of said urine collector, and the diameter of said scupper is set at a size having such a passage resistance that said urine specimen remains in said urine collector for at least a time required for measurement.

10. The urogenous component measuring apparatus in accordance with claim 1, wherein

said excitation light source part generates said excitation light including light of at least 800 nm in wavelength.

11. The urogenous component measuring apparatus in accordance with claim 10, wherein

said excitation light source of said excitation light source part is a semiconductor laser.

12. The urogenous component measuring apparatus in accordance with claim 1, wherein

said excitation light source part and said optical system including said spectro-detector are set in the exterior of said stool body, and an optical fiber member is provided between said urine collector and said excitation light source part and said optical system as a light transmission path.

13. The urogenous component measuring apparatus in accordance with claim 3, wherein the shift wavenumber has a correlation coefficient R of at least 0.9.

14. The urogenous component measuring apparatus in accordance with claim 5, wherein the shift wavenumber has a correlation coefficient R of at least 0.9.