Therapy apparatus for treating conditions of the heart and heart-proximate vessels

• US 5,817,021 A
• Filed: 10/03/1995
• Issued: 10/06/1998
• Est. Priority Date: 04/15/1993
• Status: Expired due to Term

• Current Assignee: Siemens AG
• Original Assignee: Siemens AG
• Inventors: Reichenberger, Helmut
• Primary Examiner(s): CASLER, BRIAN L
• Application Number:
  US08/525,747
• Time in Patent Office: 1,099 Days
• Field of Search: 128/660.03, 601/3, 601/2, 601/4, 607/96, 600/439
• US Class Current: 600/439
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 2017/00703 correcting for movement of heart, e.g. ECG-triggered
• CPC Class Codes: A61B 2017/22028 arrays, e.g. phased arrays
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: A61B 8/461 Displaying means of special interest
• CPC Class Codes: A61B 8/467 characterised by special input means
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0091 with moving parts, e.g. transducers, lenses, reflectors
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

In a therapy apparatus and method for treating conditions of the heart and, particularly, of heart-proximate vessels with therapeutic ultrasound waves having a therapeutically effective region. The therapy apparatus generates therapeutic ultrasound waves with such an intensity that tissue modifications, particularly necrotization, are produced in the tissue located in the region of influence. The therapy apparatus preferably contains an ultrasound source that can be transesophageally applied.

Claims

1. A therapy apparatus for treating cardiovascular conditions comprising:

an ultrasound source having means for generating therapeutic ultrasound waves having a therapeutically effective region and having an intensity for producing tissue modifications by thermal interaction with tissue located in said therapeutically effective region, said ultrasound source having dimensions adapted for intrathoracically applying said ultrasound source in a subject, and said therapeutic ultrasound source containing a plurality of spatially separated therapeutic ultrasound transducers mechanically connected in a linear structure and means for spatially orienting said therapeutic ultrasound transducers relative to each other for causing therapeutic ultrasound waves emitted by each therapeutic ultrasound transducer to be superimposed at a location to be treated.

2. A therapy apparatus as claimed in claim 1 wherein said means for generating therapeutic ultrasound waves comprises means for generating therapeutic ultrasound waves having an intensity for necrotizing said tissue located in said therapeutically effective region.

3. A therapy apparatus as claimed in claim 1 wherein said means for generating therapeutic ultrasound waves comprises means for generating therapeutic ultrasound waves having an intensity for interacting with said tissue located in said therapeutically effective region for permanently modifying said tissue.

4. A therapy apparatus as claimed in claim 1 wherein said ultrasound source further comprises a diagnostic ultrasound transducer and wherein said apparatus further comprises ultrasound locating means, connected to said diagnostic ultrasound transducer, for locating said region to be treated.

5. A therapy apparatus as claimed in claim 4 wherein said therapeutic ultrasound transducers and said diagnostic ultrasound transducer are mechanically connected in a structure in said ultrasound source of which said therapeutic ultrasound transducers and said diagnostic ultrasound transducer comprise a plurality of successive elements, said structure having an arrested condition and a non-arrested condition, and further comprising means for placing said structure in said non-arrested condition for making said structure flexible and for placing said structure in said arrested condition for making said structure rigid.

6. A therapy apparatus as claimed in claim 5 wherein said structure comprises a chain.

7. A therapy apparatus as claimed in claim 1 wherein said therapeutic ultrasound transducers are mechanically connected in a structure in said ultrasound source of which said therapeutic ultrasound transducers comprise a plurality of successive elements, said structure having an arrested condition and a non-arrested condition, and further comprising means for placing said structure in said non-arrested condition for making said structure flexible and for placing said structure in said arrested condition for making said structure rigid.

8. A therapy apparatus as claimed in claim 7 wherein said structure comprises a chain.

9. A therapy apparatus as claimed in claim 1 further comprising means for enabling emission of said therapeutic ultrasound waves from said therapeutic ultrasound transducers only during pauses in cardiac activity of said subject wherein the heart of said subject is at relative mechanical rest.

10. A therapy apparatus as claimed in claim 1 further comprising an extracorporeally applicable therapeutic ultrasound source.

11. A therapy apparatus as claimed in claim 10 wherein said extracorporeally applicable therapeutic ultrasound source comprises an intercostally applicable therapeutic ultrasound source.

12. A therapy apparatus as claimed in claim 10 wherein said extracorporeally applicable therapeutic ultrasound source comprises a subcostally applicable therapeutic ultrasound source.

13. A therapy apparatus as claimed in claim 10 wherein said extracorporeally applicable therapeutic ultrasound source emits further therapeutic ultrasound waves, and said therapy apparatus further comprising means for aligning said extracorporeally applicable therapeutic ultrasound source and said ultrasound source for superimposing said further therapeutic ultrasound waves and said therapeutic ultrasound waves at least in said therapeutically effective region.

14. A therapy apparatus as claimed in claim 13 wherein said extracorporeally applicable therapeutic ultrasound source comprises means for focusing said further therapeutic ultrasound waves onto a first focus zone.

15. A therapy apparatus as claimed in claim 14 wherein said ultrasound source comprises means for focusing therapeutic ultrasound waves emitted from at least one of said therapeutic ultrasound transducers onto a second focus zone.

16. A therapy apparatus as claimed in claim 15 wherein said first and second focus zones have respectively different sizes, with one of said focus zones being larger than the other, and further comprising means for displacing a smaller of said focus zones within a larger of said focus zones.

17. A therapy apparatus as claimed in claim 13 wherein said extracorporeally applicable therapeutic ultrasound source comprises means for emitting said further therapeutic ultrasound waves in pulses.

18. A therapy apparatus as claimed in claim 17 wherein said ultrasound source comprises means for operating at least one of said therapeutic ultrasound transducers for emitting said therapeutic ultrasound waves in pulses.

19. A therapy apparatus as claimed in claim 18 wherein said ultrasound source and said extracorporeally applicable therapeutic ultrasound source comprise, in combination, means for superimposing said therapeutic ultrasound waves and said further therapeutic ultrasound waves in said therapeutically effective region with an energy density and a pulse duration for producing a therapeutic effect in a heart of said subject during one heart cycle.

20. A therapy apparatus as claimed in claim 1 wherein said ultrasound source comprises means for operating at least one of said therapeutic ultrasound transducers for emitting said therapeutic ultrasound waves in pulses.

21. A therapy apparatus as claimed in claim 20 wherein said ultrasound source comprises means for operating said therapeutic ultrasound transducers for emitting said therapeutic ultrasound waves with an energy density and a pulse duration in said therapeutically effective region for producing a therapeutic effect in a heart of said subject during one heart cycle.

22. A therapy apparatus as claimed in claim 1 further comprising means for determining a temperature of tissue in said therapeutically effective region.

23. A therapy apparatus as claimed in claim 22 wherein said means for determining a temperature comprises means for obtaining a succession of ultrasound images, and means for identifying said temperature from said successive ultrasound images.

24. A therapy apparatus as claimed in claim 1 wherein said ultrasound source having dimensions adapted for intrathoracically applying ultrasound source in a subject comprises a transesophageally applicable ultrasound source.

25. A method for treating cardiovascular conditions in a subject comprising the steps of:

intrathoracially insonifying a cardiovascular region to be treated with therapeutic ultrasound waves having a therapeutically effective region; and

generating said therapeutic ultrasound waves with an intensity for producing cardiovascular tissue modifications due to thermal effect in cardiovascular tissue disposed in said therapeutically effective region.

26. A method as claimed in claim 25 wherein the step of generating said therapeutic ultrasound waves with an intensity comprises generating said therapeutic ultrasound waves with an intensity for necrotizing said cardiovascular tissue in said therapeutically effective region.

27. A method as claimed in claim 25 comprising the additional step of introducing a source of said therapeutic ultrasound waves into the esophagus of said subject, and wherein the step of intrathoracially insonifying said cardiovascular region with therapeutic ultrasound waves comprises insonifying said cardiovascular region with therapeutic ultrasound waves emitted from said therapeutic ultrasound source in said esophagus.

28. A method as claimed in claim 25 comprising the additional step of:

insonifying said cardiovascular tissue with further therapeutic ultrasound waves; and

generating said further therapeutic ultrasound waves from an extracorporeally applied therapeutic ultrasound source.

29. A method as claimed in claim 28 wherein the step of generating said further therapeutic ultrasound waves comprises generating said further therapeutic ultrasound waves from an intercostally applied therapeutic ultrasound source.

30. A method as claimed in claim 28 wherein the step of generating said further therapeutic ultrasound waves comprises generating said further therapeutic ultrasound waves from a subcostally applied therapeutic ultrasound source.

31. A method as claimed in claim 28 wherein the step of intrathoracically insonifying a cardiovascular region comprises intrathoracically insonifying said cardiac region with an intrathoracic source of said therapeutic ultrasound waves, and comprising the additional step of aligning said intrathoracic source of said therapeutic ultrasound waves and said extracorporeally applied therapeutic ultrasound source for superimposing said therapeutic ultrasound waves and said further therapeutic ultrasound waves in said therapeutically effective region.