Apparatus and method for isolated pelvic perfusion
First Claim
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1. Apparatus for isolated perfusion of the pelvic cavity of a patient comprising:
- a first catheter designed, sized and dimensioned for occluding the aorta of said patient;
a second catheter designed, sized and dimensioned for occluding the vena cava of said patient;
a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient;
a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient;
a pump having a suction port and a discharge port;
a first conduit for providing fluid communication between said third catheter and said suction port;
a detoxification device having an inlet and an outlet;
a second conduit for providing fluid communication between said discharge port and said inlet;
a third conduit for providing fluid communication between said outlet and said fourth catheter; and
,bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient.
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Abstract
The instant invention provides a novel apparatus, kit and process for isolating a flow circuit within the pelvic cavity of a patient for perfusing a high concentration of a chemotherapeutic agent therethrough, without contaminating the blood circulating in the substantial remainder of the patient'"'"'s blood circulatory system with the agent.
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Citations
12 Claims
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1. Apparatus for isolated perfusion of the pelvic cavity of a patient comprising:
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a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and
,bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient. - View Dependent Claims (2, 3, 4, 5)
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6. A kit comprising:
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a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; wherein said third catheter further comprises structure for percutaneous insertion into said common iliac vein, including (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end; wherein said balloons are sized and spaced on said plastic tube sufficient, that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in said common iliac vein and to substantially isolate outflow from said tumor to other portions of said common iliac vein;
fenestration in said plastic tube between said balloons to said main lumen;
second and third lumina within said plastic tube;said second lumen connecting to one of said balloons; and
,said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons; said cranial end of said plastic tube being closed to substantially all inflow of blood; and
,a return catheter for returning blood removed through said main lumen to the patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port; a first conduit for providing fluid communication between said third catheter and said suction port; a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; and
,bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient. - View Dependent Claims (7, 8, 9, 10)
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11. A method for isolated pelvic perfusion comprising the steps of:
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providing a kit which includes a first catheter designed, sized and dimensioned for occluding the aorta of said patient;
a second catheter designed, sized and dimensioned for occluding the vena cava of said patient;
a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient;
a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient;
a pump having a suction port and a discharge port;
a first conduit for providing fluid communication between said third catheter and said suction port;
a detoxification device having an inlet and an outlet;
a second conduit for providing fluid communication between said discharge port and said inlet;
a third conduit for providing fluid communication between said outlet and said fourth catheter; and
, bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient;occluding said aorta with said first catheter; occluding said vena cava with said second catheter; occluding said common iliac vein with said third catheter; occluding said common iliac artery with said fourth catheter; restricting said flow of blood with said bilateral thigh tourniquets; perfusing chemotherapeutic agents into the pelvic cavity through said first and second catheters; withdrawing toxified blood from said pelvic cavity through said third catheter; detoxifying said toxified blood with said detoxification device to provide detoxified blood; and
,reinfusing said detoxified blood through said fourth catheter.
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12. Apparatus for isolated perfusion of the pelvic cavity of a patient comprising:
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a first catheter designed, sized and dimensioned for occluding the aorta of said patient; a second catheter designed, sized and dimensioned for occluding the vena cava of said patient; a third catheter designed, sized and dimensioned for occluding the common iliac vein of said patient; a fourth catheter designed, sized and dimensioned for returning detoxified blood to the common iliac artery of said patient; a pump having a suction port and a discharge port;
a first conduit for providing fluid communication between said third catheter and said suction port;a detoxification device having an inlet and an outlet; a second conduit for providing fluid communication between said discharge port and said inlet; a third conduit for providing fluid communication between said outlet and said fourth catheter; bilateral thigh tourniquets for restricting the flow of blood between the legs and said pelvic cavity of said patient; said third catheter further comprises structure for percutaneous insertion into said common iliac vein, including (a) a plastic tube having a cranial end and a caudal end, said plastic tube defining a main lumen for outflowing blood, two balloons, fixedly spaced apart about said plastic tube and bonded thereto for inflation thereabout, one being contiguous to said cranial end; wherein said balloons are sized and spaced on said plastic tube sufficient, that when inflated, they have sufficient size and spacing therebetween to substantially block the flow of blood in said common iliac vein and to substantially isolate outflow from said tumor to other portions of said common iliac vein; fenestration in said plastic tube between said balloons to said main lumen; second and third lumina within said plastic tube; said second lumen connecting to one of said balloons; and
,said third lumen connecting to the other of said balloons for effecting inflation or deflation of said balloons; said cranial end of said plastic tube being closed to substantially all inflow of blood; a return catheter for returning blood removed through said main lumen to the patient; and said cranial end is tapered to a diameter of an angiographic guide wire.
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Specification