Compositions for passive immunotherapy

• US 5,817,312 A
• Filed: 10/14/1997
• Issued: 10/06/1998
• Est. Priority Date: 01/12/1993
• Status: Expired due to Fees

• Current Assignee: London Health Sciences Centre Research Incorporated
• Original Assignee: Medical Sciences Research Institute
• Inventors: Gristina, Anthony G., Giridhar, Girish
• Primary Examiner(s): LORING, SUSAN
• Application Number:
  US08/949,862
• Time in Patent Office: 357 Days
• Field of Search: 424/164.1, 424/150.1, 424/130.1, 424/43, 424/44, 530/387.1
• US Class Current: 424/164.1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 39/44 Antibodies bound to carriers
• CPC Class Codes: A61L 2300/256 Antibodies, e.g. immunoglobulins, vaccines
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: C07K 16/12 against material from bacteria
• CPC Class Codes: C07K 16/1214 from Pseudomonadaceae (F)
• CPC Class Codes: C07K 16/1271 from Micrococcaceae (F), e.g. Staphylococcus

Abstract

The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly decreases the rate of infection at those sites and enhances healing. The immunoglobulins serve to opsonize circulating infectants for phagocytosis and killing, prior to microbial adhesion and biofilm formation, and neutralize bacterial toxins. The treatment methodology results in reduced inflammation, reduced complement and tissue damage, and reduced rejection of biomaterials and transplants.

Claims

1. A sprayable composition, comprising:

porous delivery devices or biodegradable materials;

immunoglobulins associated with said porous delivery devices or biodegradable materials; and

a carrier.