Methods of treatment using a thieno-benzodiazepine

• US 5,817,655 A
• Filed: 11/13/1996
• Issued: 10/06/1998
• Est. Priority Date: 04/23/1991
• Status: Expired due to Term

• Current Assignee: ELI Lilly and Company Limited (Eli Lilly and Company)
• Original Assignee: Eli Lilly and Company, ELI Lilly and Company Limited (Eli Lilly and Company)
• Inventors: Hotten, Terrence Micharl, Tupper, David Edward, Chakrabarti, Jiban Kumar
• Primary Examiner(s): Shah, Mukund J.
• Assistant Examiner(s): TRUONG, TAMTHOM NGO
• Application Number:
  US08/748,292
• Time in Patent Office: 692 Days
• Field of Search: 514/220
• US Class Current: 514/220
• CPC Class Codes: A61K 31/551 having two nitrogen atoms, e.g. dilazep
• CPC Class Codes: A61K 31/5513 1,4-Benzodiazepines, e.g. diazepam or clozapine

Abstract

2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno - 2,3-b! 1,5!benzodiazepine, or an acid salt thereof, has pharmaceutical properties, and is of particular use in the treatment of disorders of the central nervous system. The compound has the following structure: ##STR1##

Claims

1. A method of treating a patient suffering from or susceptible to a psychosis selected from the group consisting of Delirium;

Organic Delusional Disorder;

Multi-infarct Dementia, With Delirium;

Multi-infarct Dementia, With Delusions;

Major Depression, Recurrent With Psychotic Features; and

Organic Hallucinosis, comprising administering to the patient an amount of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno- 2,3-b! 1,5!benzodiazepine, or an acid addition salt thereof, that is effective to treat the psychosis.

2. A method of claim 1 wherein the effective amount is from 1 to 20 mg per day of 2-methyl-4-(4-methyl -1-piperazinyl)-10H-thieno- 2,3-b! 1,5!benzodiazepine, or an acid addition salt thereof.

3. A method for treating a patient suffering from or susceptible to a psychosis selected from the group consisting of Delirium;

Psychotic Disorder Due to a Medical Condition, With Delusions;

Psychotic Disorder Due to a Medical Condition, With Hallucinations;

Vascular Dementia, With Delirium;

Vascular Dementia, With Delusions; and

Severe Recurrent Major Depressive Disorder With Psychotic Features;

comprising administering to the patient an amount of 2-methyl -4-(4-methyl-1-piperazinyl)-10H-thieno- 2,3-b! 1,5!benzodiazepine, or an acid addition salt thereof, that is effective to treat the psychosis.

4. A method of claim 3 wherein the effective amount is from 1 to 20 mg per day.

5. A method for treating a patient suffering from the psychotic condition called Primary Degenerative Dementia of the Alzheimer Type, Presenile Onset, With Delusions, comprising administering to the patient an amount of 2-methyl -4-(4-methyl-1-piperazinyl)-10H-thieno- 2,3-b! 1,5!benzodiazepine, or an acid addition salt thereof, that is effective to treat the condition.

6. The method of claim 5 wherein the effective amount is from 1 to 20 mg per day.