Particle analysis system and method

• US 5,818,583 A
• Filed: 11/08/1996
• Issued: 10/06/1998
• Est. Priority Date: 11/08/1996
• Status: Expired due to Term

• Current Assignee: Texas A&M University System
• Original Assignee: Purdue Research Foundation (Purdue University)
• Inventors: Sevick-Muraca, Eva, Jiang, Huabei, Pierce, Joseph, Kao, Jeffery
• Primary Examiner(s): Rosenberger, Richard A.
• Application Number:
  US08/747,112
• Time in Patent Office: 697 Days
• Field of Search: 356/335, 356/336, 356/342
• US Class Current: 356/336
• CPC Class Codes: G01N 15/0205 by optical means
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A system and method are disclosed for the self-calibrating, on-line determination of size distribution and volume fraction of a number of particles dispersed in a medium by detecting multiply scattered light from the particles. The multiply scattered light is re-emitted in response to exposure to a light source configured to provide light of time varying intensity at selected wavelengths. The determination includes calculating the isotropic scattering coefficient for the particles at each of a number of wavelengths from the multiply scattered light as a function of an intensity modulation phase shift, and iteratively estimating the size distribution and volume fraction as a function of the isotropic scattering coefficient for each of the wavelengths. An estimation approach based on an expected form of the distribution and the mass of the particles is also disclosed.

Claims

1. A method of particle analysis, comprising:

(a) exposing a number of particles in a particle suspension to an incident light with a time-varying intensity, the particles being sufficiently close to one another to multiply scatter light;

(b) detecting multiply scattered light from the particles in response to the incident light to provide a first value corresponding to a measurement of an optical property of the particles, the first value being determined as a function of time-dependent propagation of the multiply scattered light through the particle suspension;

(c) establishing a second value corresponding to an estimation of at least one of volume fraction and size distribution of the particles;

(d) calculating a third value as a function of the second value, the third value corresponding to a prediction of the optical property based on the estimation;

(e) comparing the first and third values to establish an error;

(f) changing the second value as a function of the error; and

(g) repeating said calculating, comparing, and changing until the error reaches a desired minimum.

2. The method of claim 1, wherein the incident light includes a number of different wavelengths of light, the first value is determined for each of the wavelengths, and said establishing, said calculating, said comparing, and said changing are performed for each of the different wavelengths.

3. The method of claim 1, further comprising controlling a chemical process by utilizing the estimation to measure output of the process.

4. The method of claim 3, wherein the particles include a number of liquid droplets.

5. The method of claim 1, wherein said establishing includes determining a number of parameters corresponding to an expected form of the size distribution of the particles, the second value being representative of one of the parameters.

6. The method of claim 5, wherein said changing includes updating the parameters and a fourth value corresponding to mass of the particles.

7. The method of claim 1, wherein the first value is determined from a diffusion equation modeling the time-dependent propagation of the multiply scattered light through the particles.

8. The method of claim 7, wherein the third value is further determined from wavelength of the incident light and a relative index of refraction of the particles.

9. A system for analyzing a number of particles suspended in a medium in sufficient concentration to multiply scatter light, comprising:

(a) a light source configured to expose the medium to a number of different wavelengths of light each being intensity-modulated at a predetermined frequency;

(b) a first sensor spaced apart from the source, the sensor being configured to provide a first detection signal corresponding to multiply scattered light from the particles at the different wavelengths in response to exposure to the source;

(c) a processor responsive to the first detection signal to generate;

(i) an observed signal for each of the wavelengths as a function of time, the observed signal being representative of an optical property of the particles in the medium, the observed signal being determined from at least one of a phase shift or a modulation amplitude of the multiply scattered light relative to the predetermined frequency for each of the wavelengths, and (ii) an output signal corresponding to a size distribution or volume fraction of the particles as a function of the observed signal or each of the wavelengths; and

(d) an output device responsive to the output signal to provide an output corresponding to the size distribution or volume fraction.

10. The system of claim 9, further comprising a reaction vessel containing the particles and medium, and wherein the output device includes a control element operatively coupled to the reaction vessel and responsive to the output to regulate a chemical reaction involving the particles.

11. The system of claim 9, wherein the processor is further configured to determine the size distribution or volume fraction as a function of mass of the particles.

12. The system of claim 9, further comprising a second sensor providing a second detection signal, the observed signal being determined as a function of the first and second detection signals for each of the wavelengths.

13. The system of claim 9, wherein the optical property corresponds to an isotropic scattering coefficient.

14. The system of claim 9, wherein the processor is configured to generate:

an estimation signal corresponding to the size distribution or volume fraction for each of the wavelengths;

a calculated signal determined as a function of the estimation signal for each of the wavelengths, the calculated signal being representative of the optical property;

a comparison signal corresponding to a comparison of the observed and calculated signals for the optical property at each of the wavelengths; and

an update signal to update the estimation signal as a function of the comparison signal.

15. The system of claim 9, wherein the observed signal for each of the wavelengths is determined in accordance with a diffusion equation modeling the time-dependent propagation of the multiply scattered light through the particles in the frequency domain.

16. A system for analyzing a number of particles suspended in a medium in sufficient concentration to multiply scatter light, comprising:

(a) a light source configured to expose the medium to a number of different wavelengths of light;

(b) a sensor spaced apart from the source, the sensor being configured to provide a emission signal corresponding to multiply scattered light from the particles at the different wavelengths in response to exposure to the source;

(c) a processor responsive to the first emission signal, the processor including a means for generating an output signal representative of a size distribution or volume fraction of the particles as a function of an isotropic scattering coefficient, the processor being configured to determine a value representative of the isotropic scattering coefficient from the emission signal; and

(d) an output device responsive to the output signal to provide an output corresponding to the size distribution or volume fraction.

17. The system of claim 16, further comprising a reaction vessel containing the particles and medium, and wherein the output device includes a control element operatively coupled to the reaction vessel and responsive to the output to regulate a chemical reaction involving the particles.

18. The system of claim 16, wherein the processor is further configured to determine the size distribution or volume fraction as a function of mass of the particles.

19. The system of claim 16, wherein the means includes:

an estimation signal corresponding to the size distribution or volume fraction for each of the wavelengths;

a calculated signal determined as a function of the estimation signal for each of the wavelengths, the calculated signal being representative of the optical property;

a comparison signal corresponding to a comparison of the observed and calculated signals for the optical property at each of the wavelengths; and

an update signal to update the estimation signal as a function of the comparison signal.

20. The system of claim 19, wherein the means includes a number of parameters corresponding to a weibull distribution.

21. A method of particle analysis, comprising:

(a) exposing a number of particles to a number of wavelengths of light of time-varying intensity;

(b) detecting multiply scattered light from the particles in response to said exposing to determine a first number of values from a mathematical relationship modeling time-dependent propagation of the multiply scattered light through the particles, the first values each being representative of an optical property of the particles and each corresponding to a different one of the wavelengths, and

(c) determining a second value representative of a size distribution of the particles as a function of the first values.

22. The method of claim 21, wherein the particles are suspended in a fluid medium and further comprising controlling a process as a function of the second value.

23. The method of claim 21, wherein the optical property is an isotropic scattering coefficient.

24. The method of claim 21, wherein the wavelengths have an intensity modulation frequency and the first values are determined as a function of phase shift of light sensed from said detecting relative to light provided by said exposing.

25. The method of claim 21, wherein the size distribution is determined as a function of mass of the particles.

26. The method of claim 21, wherein said determining includes estimating a number of parameters corresponding to an expected form of the size distribution.

27. The method of claim 21, wherein the particles are solids suspended in a liquid medium, the particles and the medium having different indices of refraction.

28. The method of claim 21, wherein the mathematical relationship corresponds to a diffusion equation model of the multiply scattered light.

29. A method of particle analysis, comprising:

(a) providing a number of particles sufficiently concentrated in a medium to multiply scatter light;

(b) sensing multiply scattered light from the particles to determine a number of observed values corresponding to an optical property of the particles; and

(c) generating an output representative of the volume fraction of the particles by comparing each of the observed values to a corresponding one of a number of calculated values, the calculated values being representative of the optical property and being determined as a function of an estimate corresponding to the volume fraction.

30. The method of claim 29, further comprising controlling a chemical reaction of the particles as a function of the output.

31. The method of claim 29, further comprising determining size distribution of the particles.

32. The method of claim 31, wherein said generating includes estimating a number of parameters corresponding to an expected type of the size distribution.

33. The method of claim 29, wherein the particles are solids and the medium is a liquid.

34. The method of claim 29, wherein the optical property is an isotropic scattering coefficient.

35. The method of claim 29, wherein the observed values are each determined from a mathematical relationship modeling the time-dependent propagation of the multiply scattered light through the particles.