Implant for use in bone surgery

• US 5,819,748 A
• Filed: 08/01/1994
• Issued: 10/13/1998
• Est. Priority Date: 11/30/1988
• Status: Expired due to Term

• Current Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Original Assignee: ED. Geistlich Soehne AG Fuer Chemische Industrie
• Inventors: Pfirrmann, Rolf Wilhelm
• Primary Examiner(s): Dawson, Glenn K.
• Application Number:
  US08/283,711
• Time in Patent Office: 1,534 Days
• Field of Search: 606/76-78, 606/229, 606/60, 606/72, 514/2, 514/21, 514/222, 514/801, 424/85.1-85.4, 424/665, 128/DIG. 8, 128/898, 623/16
• US Class Current: 128/898
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61K 31/54 having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
• CPC Class Codes: A61L 2300/204 with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

A lyophilised collagen sponge used as an implant in osteitis and other bone cavities. The said sponge has dispersed therein antibacterially effective quantities of taurolidine and/or taurultam.

Claims

1. In a method for the surgical treatment of a bacterially infected bone cavity with an implant in which the implant is introduced into the bone;

wherein the improvement comprises implanting a sponge of uncompressed lyophilised cross-linked collagen into said bacterially infected bone cavity wherein said sponge is cross-linked solely with a physiologically acceptable cross-linking agent dispersed therein;

all of said cross linking agent being an antibiotic selected from the group consisting of taurolidine and taurultam with the proviso that said cross-linking agent is the only crosslinking agent present in said sponge; and

said cross-linking agent being present in an antibacterially-effective amount.

2. The method of claim 1 wherein said treated bone has an infection caused by a microorganism which infects said bone tissue and said bacterially infected bone cavity is formed by removing substantially all infected( bone tissue from within said bone whereby said bacterially infected bone cavity contains bacteria which is capable of causing re-infection of said bone.

3. The method of claim 2 wherein said infection is selected from the group consisting of osteomyelitis and osteitis.