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Lyophilization closure assembly for a medicament container for use during a lyophilization process

  • US 5,819,964 A
  • Filed: 04/04/1997
  • Issued: 10/13/1998
  • Est. Priority Date: 09/27/1996
  • Status: Expired due to Term
First Claim
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1. A lyophilization closure assembly for a medicament container having an open top and a rim surrounding said open top, comprising:

  • a body secured about the open top of the container, the body having a distal wall disposed over the open top of the container and a skirt surrounding the rim of the container, a central passage provided on the distal wall, the skirt having a distal end, a proximal end, and one or more vapor passages formed therebetween, the body including one or more deflectable latches cooperable with the rim of the container and provided intermediate the distal and proximal ends of the skirt, the body having a first position, wherein the body is elevated from the open top of the container such that the vapor passages communicate with the open top, and a second position, wherein the deflectable latches lock the body to the rim and the vapor passages do not communicate with the open top of the container;

    an elastomeric closure secured within said body for sealing the open top of the container when the body is in the second position, the elastomeric closure having a plug for sealing the open top of the container, and a top surface facing the central passage of the distal wall, the plug dimensioned to be spaced from the open top of the container when the body is in the first position such that the open top communicates with the vapor passages of the skirt; and

    a membrane removably secured across the central passage of the distal wall and hermetically enclosing the top surface of the closure.

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