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Product and process for T cell regulation

  • US 5,820,866 A
  • Filed: 03/04/1994
  • Issued: 10/13/1998
  • Est. Priority Date: 03/04/1994
  • Status: Expired due to Term
First Claim
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1. An isolated Peptide-L-MHC heterodimer comprising:

  • a) an MHC segment of said heterodimer which forms a peptide binding groove, comprising at least a portion of an MHC class II β

    chain and at least a portion of an MHC class II α

    chain;

    b) an antigenic peptide comprising from about 5 to about 40 amino acid residues which binds to said peptide binding groove; and

    c) a linker comprising an amino acid sequence of at least about 15 amino acid residues, wherein said peptide is covalently linked by said linker to the N-terminus of one of said MHC class II α and

    β

    chains, said linker facilitating the binding of said peptide to said peptide binding groove such that said peptide and said MHC segment form a conformation that is recognized by a T cell receptor without substantially hindering interaction between said Peptide-L- MHC heterodimer and said T cell receptor;

    wherein said antigenic peptide, linker and at least one of said MHC class II α and

    β

    chains is encoded by a nucleic acid molecule, said nucleic acid molecule including a nucleic acid sequence encoding a signal segment attached to the N-terminus of said antigenic peptide.

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