Percutaneously absorbable patch

• US 5,820,878 A
• Filed: 04/28/1997
• Issued: 10/13/1998
• Est. Priority Date: 11/18/1994
• Status: Expired due to Fees

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Kojima, Masaki, Shinmura, Miyuki, Hirano, Munehiko
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Shelborne, Kathryne E.
• Application Number:
  US08/817,878
• Time in Patent Office: 533 Days
• Field of Search: 424/448, 424/449
• US Class Current: 424/449
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/565 not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61K 9/7069 obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
• CPC Class Codes: A61K 9/7076 the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins

Abstract

A percutaneously absorbable preparation-containing patch, wherein the preparation comprises: (1) a base comprising as essential ingredients a (A-B) n-A based elastomer wherein A is substantially a monovinyl-substituted aromatic compound polymer block, B is substantially a conjugated diolefin copolymer block, and n is an integer of 3-7, crotamiton, and a softening agent; and (2) at least two hormones, especially estrogen and luteal hormones, as active ingredients.

Claims

1. A percutaneously absorbable preparation-containing patch, wherein the preparation comprises:

(1) 20 to 99% by weight of a base comprising as essential ingredients;

(a) 5 to 50% by weight of a (A-B)_n -A based elastomer, wherein A is substantially a monovinyl-substituted aromatic compound polymer block, B is substantially a conjugated diolefin copolymer block, and n is an integer of 3-7,

(b) 1 to 20% by weight of crotamiton, and

(c) 10 to 70% by weight of a softening agent; and

(2) 0.01 to 10% by weight of estrogen and 0.01 to 10% by weight of a luteal hormone as active ingredients, the proportion of each ingredient being based on the total amount of the pharmaceutical preparation.

2. A patch according to claim 1, wherein the preparation further contains 5 to 40% by weight of a tackifier.

3. A patch according to claim 1, wherein the preparation further contains at most 15% by weight of a super absorbent polymer.

4. A patch according to claim 1, 2 or 3, wherein the weight ratio of the content of the luteal hormone to the content of the estrogen is 1 to 5.

5. A patch according to claim 1, 2, 3 or 4, wherein the estrogen is estradiol, estrone, equilin, equilenin or a derivative thereof.

6. A patch according to claim 1, 2, 3 or 4, wherein the luteal hormone is progesterone, hydroxy-progesterone caproate, medroxyprogesterone acetate, dydrogesterone, chlormadinone acetate, ethisterone, dimethisterone, norethisterone, norethisterone acetate, norethisterone enanthate, ethynodiol acetate, megestrol acetate or allylestrenol.

7. A patch according to claim 1, 2, 3, 4, 5 or 6, wherein the preparation is in a dosage form of a plaster.