×

Propargylethoxyamino nucleotides

  • US 5,821,356 A
  • Filed: 08/13/1996
  • Issued: 10/13/1998
  • Est. Priority Date: 08/12/1996
  • Status: Expired due to Term
First Claim
Patent Images

1. A nucleoside compound having the structure:

  • ##STR12## wherein;

    R1 and R2 taken separately are selected from the group consisting of --H, lower alkyl, protecting group, and label;

    B is a 7-deazapurine, purine, or pyrimidine nucleoside base;

    wherein when B is purine or 7-deazapurine, the sugar moiety is attached at the N9 -position of the purine or deazapurine, and when B is pyrimidine, the sugar moiety is attached at the N1 -position of the pyrimidine; and

    wherein when B is a purine, the adjacent triple-bonded carbon is attached to the 8-position of the purine, when B is 7-deazapurine, the adjacent triple-bonded carbon is attached to the 7-position of the 7-deazapurine, and when B is pyrimidine, the adjacent triple-bonded carbon is attached to the 5-position of the pyrimidine;

    W1 is selected from the group consisting of --H and --OH;

    W2 is --OH or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3'"'"'-position; and

    W3 is selected from the group consisting of --PO4, --P2 O7, --P3 O10, phosphate analog, and --OH.

View all claims
  • 8 Assignments
Timeline View
Assignment View
    ×
    ×