Method for welding biological tissue

• US 5,824,015 A
• Filed: 06/05/1995
• Issued: 10/20/1998
• Est. Priority Date: 02/13/1991
• Status: Expired due to Fees

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Fusion Medical Technologies Inc. (Baxter International Inc.)
• Inventors: Sawyer, Philip N.
• Primary Examiner(s): Bawa, Raj
• Application Number:
  US08/461,227
• Time in Patent Office: 1,233 Days
• Field of Search: 424/400, 606/7, 606/8, 606/10, 606/12, 606/17, 606/213, 606/214, 606/40, 606/3, 606/215, 606/153, 606/154, 606/155, 606/32, 128/898
• US Class Current: 606/214
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61F 2310/00365 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 27/24 Collagen

Abstract

A method for joining or reconstructing biological tissue comprises providing a solid filler material in the form of a preformed sheet, where the sheet comprises collagen, gelatin or a mixture thereof. The filler material is placed over tissue. Radiofrequency energy or optical energy is thereafter applied to the filler material in an amount sufficient to melt or denature the filler material.

Claims

1. A method of joining or reconstructing biological tissue, said method comprising the following steps:

providing a solid filler material in the form of a preformed sheet, wherein the sheet comprises collagen, gelatin, or a mixture thereof;

placing the filler material over said biological tissue prior to applying energy, and

applying radiofrequency or optical energy to the filler material in an amount sufficient to melt or denature the filler material while said filler material is over the said biological tissue.

2. A method as in claim 1, wherein the filler material is cut to a desired size prior to placing on the tissue.

3. A method as in claim 1, wherein the energy is radiofrequency energy applied from an inert gas beam coagulator.

4. A method as in claim 1, further comprising applying a tissue adhesive to the tissue prior to placing the filler material.

5. A method of joining or restructuring biological tissue, said method comprising the following steps:

providing a filler material in the form of a preformed sheet which fuses to said biological tissue upon the application of energy, wherein the filler material comprises collagen, gelatin, or a mixture thereof;

placing the filler material over said biological tissue to be joined or restructured prior to applying energy; and

applying radiofrequency energy to the filler material in an amount sufficient to melt or denature the filler material and the said biological tissue after said filler material has been placed over the said biological tissue, wherein the radiofrequency energy is applied from an inert gas beam radiofrequency device.

6. A method as in claim 5, wherein the radiofrequency inert gas beam device is operated at between about 20 and 120 watts for about 1 to 60 seconds, so that about 20 to 1800 joules are delivered to the filler material and the biological tissue.

7. A method as in claim 6, wherein the radiofrequency inert gas beam device is operated at between about 35 and 80 watts for about 5 to 40 seconds, so that about 100 to 1200 joules are delivered to the filler material and the biological tissue.

8. An improved method for joining or reconstructing biological tissue wherein a collagen- or gelatin-containing material is placed over the tissue and energy is thereafter applied to fuse the material and tissue together, wherein the improvement comprises the step of applying radiofrequency energy to the material and said tissue under conditions which result in about 20 to 1800 joules of energy being delivered to the collagen or gelatin-containing material and the said tissue.

9. An improved method as in claim 8, wherein the collagen-containing material is in the form of a preformed a sheet.

10. An improved method as in claim 8, wherein the radiofrequency device is operated at between about 20 and 120 watts for about 1 to 60 seconds.

11. An improved method as in claim 8, wherein the radiofrequency device is operated at between about 35 and 80 watts for about 5 to 30 seconds, so that about 100 to 1200 joules are delivered to the collagen-containing material and the biological tissue.

12. An improved method as in claim 8, wherein the collagen-containing material is composed of a material selected from the group consisting of native collagen, collagen cast with a plasticizer, and gelatin.