Nerve cuff having one or more isolated chambers

• US 5,824,027 A
• Filed: 08/14/1997
• Issued: 10/20/1998
• Est. Priority Date: 08/14/1997
• Status: Expired due to Term

• Current Assignee: Simon Fraser University
• Original Assignee: Simon Fraser University
• Inventors: Hoffer, Joaquin Andreas, Strange, Kevin D., Chen, Yunquan, Christensen, Paul Richard
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US08/911,604
• Time in Patent Office: 432 Days
• Field of Search: 607/118, 607/148, 600/372, 600/373, 600/377, 600/393, 604/93, 604/179, 604/20, 604/174, 604/175, 604/280, 604/264
• US Class Current: 607/118
• CPC Class Codes: A61N 1/0556 Cuff electrodes

Abstract

A nerve cuff has one or more sets of electrodes for selectively recording electrical activity in a nerve or for selectively stimulating regions of the nerve. Each set of electrodes is located in a longitudinally extending chamber between a pair of longitudinal ridges which project into the bore of the nerve cuff. The ridges are electrically insulating and serve to improve the selectivity of the nerve cuff. The ridges seal against an outer surface of the nerve without penetrating the nerve. Nerve cuffs according to the invention may be used in functional electrical stimulation systems. Electrodes may be replaced with fine tubes to enable pharmacological agents to be delivered selectively through the tubes to portions of a nerve passing through the cuff or to permit the sampling of fluids from regions adjacent selected outer portions of the nerve. The nerve cuff may be constructed of modular segments which can be selected to provide a customized fit to the shape and size of a nerve at time of implantation.

Claims

1. A nerve cuff comprising:

(a) an electrically insulating tubular cuff body of a biocompatible material penetrated by a bore for receiving a nerve, the cuff body having a closure for permitting passage of a nerve into the bore;

(b) a plurality of electrically insulating blunt longitudinal ridges extending generally longitudinally on an inner surface of the cuff body and projecting into the bore, adjacent pairs of the longitudinal ridges defining a plurality of chambers extending generally longitudinally in the bore; and

,

(c) an electrode in each of a plurality of the chambers, the electrode located between a pair of adjacent ones of the longitudinal ridges.

2. The nerve cuff of claim 1 wherein each of the longitudinal ridges comprises a soft pliable material.

3. The nerve cuff of claim 2 wherein each of the longitudinal ridges comprises an elongated tubular member.

4. The nerve cuff of claim 3 wherein the longitudinal ridges extend along substantially an entire length of the cuff body.

5. The nerve cuff of claim 4 wherein the tubular member has a wall having a thickness in the range of 0.05 mm to 0.25 mm.

6. The nerve cuff of claim 1 wherein the longitudinal ridges extend substantially an entire length of the cuff body.

7. The nerve cuff of claim 6 comprising first and second circumferential sealing ridges at first and second ends of the bore wherein the longitudinal ridges extend between the first and second circumferential sealing ridges.

8. The nerve cuff of claim 7 wherein each of the longitudinal ridges has a generally semi-circular cross sectional profile.

9. The nerve cuff of claim 6 wherein the longitudinal ridges project into the bore by approximately 5% to 20% of an internal diameter of the bore.

10. The nerve cuff of claim 9 comprising a set of three spaced apart electrodes arranged in a line along each chamber midway between each pair of adjacent ones of the longitudinal ridges.

11. The nerve cuff of claim 10 wherein two outermost ones of the electrodes in each chamber are electrically shorted together.

12. The nerve cuff of claim 10 wherein the closure comprises a pair of spaced apart first apertured members affixed to the cuff body at a first edge of a slit in the cuff body, the first apertured members having apertures aligned generally with the slit;

a second apertured member capable of being interdigitated between the first apertured members and affixed to the cuff body at a second edge of the slit, the second apertured member having an aperture aligned generally with said slit; and

an elongated locking member capable of being inserted to extend through the apertures of the first apertured members and the second apertured member when the second apertured member is interdigitated with the first apertured members.

13. The nerve cuff of claim 1 wherein the cuff body comprises a self curling sheet biased to curl about an axis and the longitudinal ridges extend generally parallel to the axis.

14. The nerve cuff of claim 1 wherein the cuff body comprises a plurality of linked segments, each of the segments comprising a cuff body portion bearing a longitudinally extending blunt ridge member, each segment spanning a portion of a circumference of the nerve cuff.

15. The nerve cuff of claim 14 wherein the ridge member on each segment comprises a curved flap extending from the cuff body portion.

16. The nerve cuff of claim 15 wherein the curved flap on each segment extends along a lateral edge of the segment and overlaps a closure linking the segment to an adjacent segment.

17. The nerve cuff of claim 16 wherein the curved flap is spaced slightly inwardly from the closure.

18. The nerve cuff of claim 17 wherein the closure comprises two or more spaced apart first apertured members affixed to the first lateral edge of a first adjacent segment, the first apertured members having apertures aligned generally with the first lateral edge of the first segment;

one or more second apertured members capable of being interdigitated between the first apertured members and affixed to a second lateral edge of a second adjacent segment, the second apertured members having apertures aligned generally with the second lateral edge of the second adjacent segment; and

an elongated locking member capable of being inserted to extend through the apertures of the first apertured members and the second apertured members when the second apertured members are interdigitated with the first apertured members.

19. A nerve cuff comprising:

(a) fluid impermeable tubular cuff body penetrated by a bore for receiving a nerve, the cuff body having a closure for permitting passage of a nerve into the bore;

(b) a plurality of fluid impermeable rounded longitudinal ridges extending generally longitudinally on an inner surface of the cuff body and projecting into the bore, adjacent pairs of the longitudinal ridges defining a plurality of chambers extending generally longitudinally in the bore; and

,

(c) a plurality of tubes, each one of the plurality of tubes extending into a different one of a plurality of the chambers for carrying fluid into or out of the chamber.

20. The nerve cuff of claim 19 comprising two or more tubes extending into each of one or more of the chambers.

21. The nerve cuff of claim 19 wherein each of the longitudinal ridges comprises an elongated tubular member.

22. The nerve cuff of claim 21 wherein the longitudinal ridges extend substantially an entire length of the cuff body.

23. The nerve cuff of claim 21 wherein the tubular member has a wall having a thickness in the range of 0.05 mm to 0.25 mm.

24. The nerve cuff of claim 19 comprising first and second circumferential sealing ridges at first and second ends of the bore wherein the longitudinal ridges extend between the first and second circumferential sealing ridges.

25. The nerve cuff of claim 24 wherein each of the longitudinal ridges has a generally semi-circular cross sectional profile.

26. The nerve cuff of claim 24 wherein each of the longitudinal ridges has a generally circular cross sectional profile.

27. A nerve cuff comprising:

(a) a segment comprising a cuff body wall portion;

(b) first and second longitudinally extending blunt ridge members extending along the cuff body wall portion and defining an open-sided chamber extending between the first and second ridges;

(c) a band member connectible between first and second sides of the cuff body wall portion to define a bore; and

,

(d) one or more electrodes or one or more fluid conduits extending into the chamber;

wherein the band member is capable of holding the cuff body wall portion to a nerve passing through the bore with the ridges sealing against an outer surface of the nerve and the nerve closing the open side of the chamber.

28. A method for selectively interfacing to a nerve, the method comprising the steps of:

(a) providing a nerve cuff, the nerve cuff comprising;

(i) a tubular cuff body penetrated by a bore for receiving a nerve, the cuff body having a closure for permitting passage of a nerve into the bore;

(ii) a plurality of longitudinal ridges extending generally longitudinally on an inner surface of the cuff body and projecting into the bore, adjacent pairs of the longitudinal ridges defining a plurality of chambers extending generally longitudinally in the bore; and

,

(iii) in at least one of the chambers, an interface comprising at least one electrode or at least one fluid port;

(b) dissecting a nerve from surrounding tissues;

(c) opening the closure and placing the cuff around the nerve with the chambers extending along portions of the nerve;

(d) closing the closure, thereby bringing the ridges into sealing contact with an outer surface of the nerve without penetrating the outer surface of the nerve; and

,

(e) either stimulating selected portions of the nerve by introducing electrical signals via the at least one electrode or pharmacological agents via the at least one fluid port into selected ones of the chambers or monitoring selected portions of the nerve by measuring electrical potentials in the chambers or sampling fluids from the chambers.