Fragrances and flavorants

• US 5,824,345 A
• Filed: 06/07/1995
• Issued: 10/20/1998
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Emisphere Technologies, Inc. (Novo Nordisk A/S)
• Original Assignee: Emisphere Technologies, Inc. (Novo Nordisk A/S)
• Inventors: Milstein, Sam J.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Spear, James M.
• Application Number:
  US08/484,293
• Time in Patent Office: 1,231 Days
• Field of Search: 424/489, 424/401, 424/455, 514/772.3, 514/773, 514/783, 514/844, 514/951, 514/963, 264/4, 264/4.1
• US Class Current: 424/489
• CPC Class Codes: A23L 27/72 Encapsulation
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/645 Proteins of vegetable origin; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61L 9/042 with the help of a macromolecular compound as a carrier or diluent A61L9/048 takes precedence
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: B01J 13/02 Making microcapsules or microballoons for medical preparations A61K9/50

Abstract

Compositions useful in the delivery of fragrances and flavorant active agents, and particularly vaporous fragrances and flavorants, are provided. These compositions include a microsphere which includes (a) the active agent; and (b) (i) a proteinoid, (ii) a modified hydrolyzed vegetable protein wherein the protein is modified with an amino reactive agent, or (iii) a combination thereof. Also contemplated is a method for preparing these compositions wherein the active agent is mixed with the proteinoid of hydrolyzed vegetable protein solution and the proteinoid or modified hydrolyzed vegetable protein is precipitated out of the solution, thereby forming a microsphere containing the active agent. In a further embodiment, the active agent is applied to a substrate.

Claims

1. A composition comprising a microsphere, said microsphere comprising:

(a) an active agent comprising a member selected from the group consisting of a perfume, a vapor, or a combination thereof, and

(b) (i) a proteinoid, (ii) a modified hydrolyzed vegetable protein wherein said protein is modified with an amine reactive agent, or (iii) a combination thereof;

wherein said microsphere can release the active agent.

2. A composition as defined in claim 1, wherein said active agent comprises a perfume.

3. A method for applying an active agent to a substrate, said method comprising contacting said substrate with a composition as defined in claim 1.

4. A composition as defined in claim 1, wherein said active agent comprises a vapor.

5. A composition as defined in claim 1, wherein said proteinoid comprises mixed amino acids.

6. A composition as defined in claim 5, wherein said proteinoid comprises a polymer of mixed amino acids.

7. A composition as defined in claim 1, wherein said proteinoid comprises a condensation polymer.

8. A composition as defined in claim 7, wherein said proteinoid comprises a thermal condensation polymer.

9. A composition as defined in claim 1, wherein said proteinoid comprises a directed polymer.

10. A composition as defined in claim 1, wherein said proteinoid comprises a random polymer.

13. A composition as defined in claim 1, wherein said amine reactive modifying group is selected from the group consisting of a benzene sulfonyl group, a benzoyl group, a phthaloyl group, a tetrahydrophthaloyl group, and a cyclohexanoyl group.

14. A composition as defined in claim 1, wherein said microsphere comprises a microcapsule.

15. A composition as defined in claim 14, wherein said microcapsule is non-porous.

16. A method as defined in claim 3, wherein said substrate comprises skin.

17. A composition as defined in claim 16, wherein said composition is adapted to release said active agent at an acidic pH.

18. A composition as defined in claim 16, wherein said composition is adapted to release said active agent at an basic pH.

19. A composition as defined in claim 16, wherein said composition is adapted to release said active agent at a neutral pH.

20. A composition as defined in claim 1, wherein said microsphere has a diameter less than of 10 μ

m.

22. A method for preparing a composition as defined in claim 1.

11. A composition comprising a microsphere, said microsphere comprising:

(a) an active agent comprising a member selected from the group consisting of a perfume, a vapor, and a combination thereof, and

(b) (i) a proteinoid comprising a diketopiperazine, (ii) a modified hydrolyzed vegetable protein wherein said protein is modified with an amine reactive agent, or (iii) a combination thereof;

wherein said microsphere can release the active agent.

12. A composition comprising a microsphere, said microsphere comprising:

(a) an active agent comprising a member selected from the group consisting of a perfume, a vapor, and a combination thereof, and

(i) a proteinoid, (ii) a modified hydrolyzed vegetable protein comprising acid hydrolyzed soybean protein, wherein said protein is modified with an amine reactive agent, or (iii) a combination thereof;

wherein said microsphere can release the active agent.

21. A composition comprising:

(a) a vaporous active agent, in

(b) a microsphere comprising a proteinoid, a modified hydrolyzed vegetable protein wherein said protein is modified with an amine reactive agent, or a combination thereof;

wherein said microsphere can release the active agent.