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Method of measuring chemical concentration iontophoretically using impermeable mask

  • US 5,827,183 A
  • Filed: 10/29/1997
  • Issued: 10/27/1998
  • Est. Priority Date: 09/12/1995
  • Status: Expired due to Term
First Claim
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1. A method of measuring a concentration of a chemical present in a bloodstream of a mammalian subject, comprising the steps of:

  • contacting a mammalian subject'"'"'s skin with a sensor assembly comprising;

    a) an ionically conductive material in contact with the skin;

    b) a working electrode in contact with the ionically conductive material the working electrode having a catalytic surface; and

    c) a mask having an opening therein wherein the mask is positioned between the skin and the working electrode;

    transporting a chemical through the skin and ionically conductive material whereby the mask blocks flow to the catalytic surface except for flow substantially axial to the catalytic surface;

    monitoring an electrical signal generated at the working electrode by catalytic conversion into an electric signal at the catalytic surface of the working electrode;

    wherein the electrical signal generated at the working electrode over a given period of time is correlated with a concentration of chemical present in the bloodstream of the mammalian subject.

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