Method and PDT probe for minimizing CT and MRI image artifacts

• US 5,827,186 A
• Filed: 04/11/1997
• Issued: 10/27/1998
• Est. Priority Date: 04/11/1997
• Status: Expired due to Term

• Current Assignee: Purdue Pharmaceutical Products LP (Purdue Pharma L.P.)
• Original Assignee: Light Sciences Limited Partnership
• Inventors: Chen, James C., Wiscombe, Brent
• Primary Examiner(s): CASLER, BRIAN L
• Application Number:
  US08/827,832
• Time in Patent Office: 564 Days
• Field of Search: 604/19-21, 600/407, 600/410, 600/421, 600/422, 600/425, 600/411, 600/427, 607/88, 607/89, 607/92, 606/14-17
• US Class Current: 600/407
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0653 Organic light emitting diodes
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: G01R 33/285 Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
• CPC Class Codes: H05K 2201/10106 Light emitting diode [LED]
• CPC Class Codes: H05K 2201/10636 Leadless chip, e.g. chip capacitor or resistor
• CPC Class Codes: H05K 2203/1311 Foil encapsulation, e.g. of mounted components
• CPC Class Codes: H05K 3/284 for encapsulating mounted components H05K1/185 takes precedence
• CPC Class Codes: H05K 3/321 by conductive adhesives
• CPC Class Codes: Y02P 70/50 Manufacturing or production processes characterised by the final manufactured product

Abstract

An implantable probe having a non-metallic insulating base, non-metallic conductive traces supported by the base, and a plurality of non-metallic light sources supported by the base and coupled to the conductive traces. The conductive traces and the light sources are fabricated from a conductive polymer, which does not cause any artifacts if the implantable probe is left at the treatment site while it is imaged. Further, the implantable probe includes an envelope that is transparent and hermetically encloses the base, the pair of conductive traces, and the light sources. At least a portion of the envelope is optically transparent, enabling light emitted by the light sources to illuminate an adjacent treatment site. The conductive traces and the base are substantially flexible, enabling the probe to be flexed without breaking when the implantable probe is advanced within the body to the treatment site. A non-metallic receiver coil implanted in a patient'"'"'s body is energized by inductively coupling it to an external transmitter coil. The current from the receiver coil is conveyed to the implanted probe through non-metallic leads.

Claims

1. An implantable probe for use in administering a medical therapy to an internal treatment site within a patient'"'"'s body, and for minimizing imaging artifacts in images produced to evaluate a condition of the internal treatment site, comprising:

(a) a non-metallic insulating base;

(b) a plurality of non-metallic conductive traces supported by the base, adapted to couple to a power supply to convey an electrical current supplied by the power supply; and

(c) a non-metallic electronic component supported by the base and coupled to the conductive traces, said non-metallic electronic component being energized by the electrical current conveyed by the plurality of non-metallic conductive traces to produce the medical therapy, said implantable probe being thus configured to remain disposed at the treatment site when the treatment site is imaged, without causing an imaging artifact that would obscure the treatment site in said images.

2. The implantable probe of claim 1, wherein the conductive traces comprise a conductive polymer.

3. The implantable probe of claim 1, wherein the non-metallic electronic component comprises a light emitting device.

4. The implantable probe of claim 1, wherein the non-metallic electronic component comprises a light emitting polymer.

5. The implantable probe of claim 1, wherein the non-metallic electronic component comprises an organic film light emitting device.

6. The implantable probe of claim 1, further including an envelope comprising a biocompatible material for hermetically enclosing the base, the plurality of non-metallic conductive traces, and the non-metallic electronic component.

7. The implantable probe of claim 1, wherein the base and the conductive traces are substantially flexible.

8. The implantable probe of claim 1, wherein the non-metallic base is substantially light reflective.

9. The implantable probe of claim 1, further comprising a plurality of non-metallic electronic components, wherein the plurality of non-metallic electronic components are disposed on opposite surfaces of the non-metallic base.

10. The implantable probe of claim 1, wherein the implantable probe has a shape generally corresponding to one of a cylinder, a sphere, a rectangular sheet, a disk, and a rectangular solid.

11. The implantable probe of claim 1, further comprising a non-metallic receiver coil that is implantable within the patient'"'"'s body and which is connected to the non-metallic conductive traces through non-metallic conductive leads, said non-metallic receiver coil being adapted to inductively couple to an external transmitter coil energized with a time varying electrical current from an external power source, the electrical current that is thereby induced in said non-metallic receiver coil energizing said non-metallic electrical component.

12. A method for providing a medical therapy to a treatment site inside a patient'"'"'s body, while avoiding artifacts in images made of the treatment site by apparatus used to administer the medical therapy, comprising the steps of:

(a) providing an implantable probe that comprises non-metallic components, including a plurality of non-metallic conductors for conveying an electrical current, and a non-metallic electrical component coupled to the non-metallic conductors and energized by the electrical current to provide the medical therapy;

(b) placing the implantable probe at the treatment site;

(c) energizing the non-metallic electrical component to administer the medical therapy to the internal treatment site; and

(d) imaging the treatment site while the implantable probe is disposed adjacent thereto, use of said non-metallic components in the implantable probe substantially eliminating artifacts in images produced thereby.

13. The method of claim 12, wherein the plurality of non-metallic conductors comprise a conductive polymer.

14. The method of claim 12, wherein the non-metallic electrical component comprises a plurality of light emitting devices disposed in an array within the implantable probe.

15. The method of claim 12, wherein the non-metallic electrical component comprises a light emitting polymer.

16. The method of claim 12, wherein the non-metallic electrical component comprises an organic film light emitting device.

17. The method of claim 12, further comprising the step of enclosing the non-metallic conductive traces and non-metallic electrical component within a hermetically sealed biocompatible envelope.

18. The method of claim 12, further comprising the step of evaluating the condition of the treatment site based upon the images produced, and as a function of said evaluation, selectively energizing the non-metallic electrical component to administer additional medical therapy to the treatment site.

19. The method of claim 12, wherein the step of imaging includes the step of using one of a computed tomography apparatus and a magnetic resonance imaging apparatus to produce the images of the treatment site.

20. The method of claim 12, wherein the non-metallic conductors are substantially flexible.

21. The method of claim 12, wherein the non-metallic base is substantially light reflective.

22. The method of claim 12, further comprising the step of providing a plurality of non-metallic electronic devices disposed on opposite sides of the non-metallic base.

23. The method of claim 12, wherein the implantable probe has a shape that is generally like one of a cylinder, a sphere, a rectangular sheet, a disk, and a rectangular solid.

24. The method of claim 12, further comprising the steps of:

(a) implanting a non-metallic receiver coil within the patient'"'"'s body;

(b) connecting the non-metallic receiver coil to the non-metallic electrical component through non-metallic conductive leads that are connected to the non-metallic conductors; and

(c) inducing an electrical current to flow in the non-metallic receiver coil with an external transmitter coil that is coupled to an external power source, for energizing the non-metallic electrical component.

25. An implantable probe for use in administering light therapy to an internal treatment site within a patient'"'"'s body, said apparatus minimizing imaging artifacts in images produced to evaluate a condition of the treatment site in response to the light therapy, comprising:

(a) a non-metallic insulating base;

(b) a pair of non-metallic conductive traces supported by the base, adapted to couple to a power supply and convey an electrical current provided by said power supply; and

(c) a non-metallic light source supported by the base and coupled to the conductive traces, said non-metallic light source being energized by the electrical current conveyed by the non-metallic conductive traces to produce light employed for the light therapy, said implantable probe being thus configured to remain disposed at the treatment site while the treatment site is imaged without causing an imaging artifact that would obscure the treatment site in images produced thereby.

26. A method for providing light therapy to a treatment site inside a patient'"'"'s body, without causing artifacts in images made of the treatment site while apparatus used to administer the light therapy remains at the treatment site, comprising the steps of:

(a) providing an implantable probe that comprises non-metallic components, including a plurality of non-metallic conductors for conveying an electrical current, and a non-metallic light source that is energized by the electrical current conveyed by the non-metallic conductors;

(b) positioning the implantable probe at the treatment site;

(c) applying a photoreactive agent to the treatment site, said photoreactive agent being preferentially absorbed by tissue at the treatment site and having an absorption waveband substantially within a waveband of light produced by the light source;

(d) energizing the light source with the electrical current to illuminate the treatment site for a period of time; and

(e) imaging the treatment site while the implantable probe remains disposed adjacent thereto, use of said non-metallic components in the implantable probe minimizing creation of artifacts in images produced thereby.