Process and apparatus for harvesting tissue for processing tissue and process and apparatus for re-injecting processed tissue

• US 5,827,217 A
• Filed: 09/04/1996
• Issued: 10/27/1998
• Est. Priority Date: 09/04/1996
• Status: Expired due to Fees

• Current Assignee: Tissue Harvest Systems, LLC
• Original Assignee: Tissue Harvest Systems, LLC
• Inventors: Chernomorsky, Ary S., Silver, Frederick H.
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): LEWIS, WILLIAM W
• Application Number:
  US08/708,307
• Time in Patent Office: 783 Days
• Field of Search: 606/1, 606/184-187, 606/131-133, 604/28, 623/15, 435/1, 128/749-755
• US Class Current: 604/28
• CPC Class Codes: A61B 10/0233 Pointed or sharp biopsy instruments
• CPC Class Codes: A61B 17/1637 Hollow drills or saws producing a curved cut, e.g. cylindrical A61B10/025, A61B17/1695 take precedence
• CPC Class Codes: A61B 2017/0046 with a releasable handle; with handle and operating part separable for prosthetic joint-implanting tools A61F2/4603
• CPC Class Codes: A61B 2017/00969 used for transplantation
• CPC Class Codes: A61F 2/4601 for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
• CPC Class Codes: A61F 2002/4635 using minimally invasive surgery
• CPC Class Codes: A61F 2002/4649 Bone graft or bone dowel harvest sites
• CPC Class Codes: A61L 27/3683 subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment

Abstract

There is disclosed a method and apparatus for harvesting tissue using a cannula having a diameter of from 0.5 to 4.0 mm and of a length of from 25 to 20 cm to access by minimally invasive techniques a host to withdraw autogenous tissue processed to remove loose fat and/or fragmented tissue. Thereafter, the resulting tissue substrate is morcellated to form particulate tissue of a particle size of from 1 to 200 μm. The particulate material is thence passed through screens having opening sizes of from 1 to 100 μm to form a material of a size for introduction into a syringe of from 16 to 30 gauge for implantation in the host. The processed tissue may be admixed with extenders, gelling agents and the like.

Claims

1. A process for harvesting tissue, which comprises:

a.) effecting an incision in a host;

b.) introducing a cannula having a diameter of about 0.5 to 4.0 mm and a length of from about 2.5 to 20 cm;

c.) withdrawing a tissue substrate from the host;

d.) admixing a buffer with said tissue substrate;

e.) removing loose fat or fragmental tissue from the admixture of step d to form processed tissue;

f.) morcellating the processed tissue of step e; and

g.) comminuting the morcellated processed tissue of step f.

2. The process for treating a tissue substrate as defined in claim 1 wherein step f is effected at rotational blade speeds of from 100 to 10,000 RPM'"'"'s.

3. The process for treating a tissue substrate as defined in claim 2 wherein morcellation is effected for a period of time of from 20 seconds to 5 minutes.

4. The process or treating a tissue substrate as defined in claim 1 wherein comminuting of step g results in a tissue substrate of a particle size for introduction into a syringe of 16 to 30 gauge.

5. A process for introducing autogenous tissue into a host donor of a tissue substrate which comprises the steps of:

a) admixing a buffer with said tissue substrate;

b) removing loose fat or fragmented tissue from the admixture of step a);

c) morcellating the resulting tissue of step b);

d) comminuting the morcellated tissue of step c); and

e) introducing into said host donor the comminuted morcellated tissue of step d).

6. The process for introducing autogenous tissue into a host donor as defined in claim 5 wherein step d) is effected to form comminuted morcellated tissue of a particle size for introduction into a syringe of 16 to 30 gauge.

7. The process for introducing autogenous tissue into a host donor as defined in claim 5 wherein step c) is effected at rotational blade speeds of from 100 to 10,000 RPM'"'"'s.

8. The process for introducing autogenous tissue into a host donor as defined in claim 5 wherein step e) is effected for a period of time of from 20 seconds to 5 minutes.