Syringe device for mixing two compounds

• US 5,827,262 A
• Filed: 03/07/1996
• Issued: 10/27/1998
• Est. Priority Date: 09/07/1993
• Status: Expired due to Fees

• Current Assignee: Debiotech S.A.
• Original Assignee: Debiotech S.A.
• Inventors: Bouvier, Bernard, Neftel, Frederic
• Primary Examiner(s): Coggins, Wynn Wood
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/617,838
• Time in Patent Office: 964 Days
• Field of Search: 604/82, 604/86, 604/87, 604/88, 604/411, 604/414, 604/415
• US Class Current: 604/414
• CPC Class Codes: A61J 1/201 having one piercing end
• CPC Class Codes: A61J 1/2065 having aligning and guiding means
• CPC Class Codes: A61J 1/2075 for external venting
• CPC Class Codes: A61J 1/2082 for gas filtration
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 2005/31516 reducing dead-space in the syringe barrel after delivery
• CPC Class Codes: A61M 5/321 Means for protection against accidental injuries by used needles
• CPC Class Codes: A61M 5/3213 Caps placed axially onto the needle, e.g. equipped with finger protection guards axially-extensible protective sleeves A61M5/3243

Abstract

A syringe device for mixing two compounds is provided. The syringe device includes a vial having an opening and a centrally perforable stopper. The syringe device also includes a guide tube for guiding the injection end of the syringe between a withdrawn or storage position and an inserted position. The guide tube includes a second end for receiving the injection end of the syringe, which also includes a seal between the body of the syringe and the guide tube.

Claims

1. A syringe device making it possible to mix two compounds, at least the first of which is liquid, comprising:

a syringe provided with a body having an injection end, the syringe adapted to contain said first compound;

means for guiding the injection end of said syringe body in translation between a first withdrawn storage position and a second inserted active position, said guide means including an inner face, a first end emerging opposite the perforable zone of a stopper capable of closing in leaktight manner the opening of a vial intended to contain the other compound and a second end for receiving the injection end of said syringe, said second end comprising means for providing sufficient linkage between said syringe and said guide means while allowing said translation;

an annular seal surrounding said syringe body and secured to said syringe body and disposed between said body and said guide means and close to the second end of the guide means when the syringe is in its first position, said annular seal having an outer face provided with at least one sealing lip for cooperating with the inner face of the guide means; and

communication means for allowing perforation of said stopper and communication of the internal volume of said syringe with the inside of said vial when the injection end of said syringe is brought into its second position.

2. Syringe device according to claim 1, wherein said linking means comprise a crimping capsule mounted on said first end of said guide means and capable of being crimped into a collar of the opening of said vial during the fastening of said guide means on said vial.

3. Syringe device according to claim 1, wherein said linking means comprise clip tabs interacting with the periphery of the opening of the vial.

4. Syringe device according to claim 3, wherein said clip means furthermore comprise a crimping ring interacting with the clip tabs.

5. Syringe device according to claim 1 wherein the communication means comprise a needle mounted at the injection end of the syringe and whose tip is capable of perforating the central zone of the stopper when the end of the syringe is brought into its second position.

6. Syringe device according to claim 1, wherein said stopper is preperforated.

7. Syringe device according to claim 1, wherein said first sealing means are capable of providing said sealing during the relative displacement of said syringe with respect to the guide means.

8. The syringe device according to claim 7, wherein said seal is made of elastomer.

9. The syringe device according to claim 7, wherein said seal is made of plastic.

10. Syringe device according to claim 1, wherein said seal has the form of a ring whose face which interacts with the body of the syringe includes at least two sealing lips.

11. Syringe device according to claim 1, wherein said seal comprises temporary means for translational linkage with the body of said syringe when said syringe is displaced between its first position and its second position.

12. The syringe device according to claim 11, wherein said temporary linkage means comprise a shoulder made on the face of the seal interacting with a relief of the body of the syringe, whereby said seal is moved along when the syringe body is inserted.

13. The syringe device according to claim 12, wherein said interaction means provide sealing between said seal and said syringe body.

14. The syringe device according to claim 11, wherein said seal includes a first locking element capable of interacting with a second locking element when said seal is in its second position.

15. The syringe device according to claim 11, wherein the face of said seal interacting with the guide piece includes at least two sealing lips.

16. Syringe device according to claim 1, wherein the first sealing means consist of a seal having the shape of an annular ring linked in translation with the syringe in the insertion direction, said ring having, on its external face, sealing lips interacting with the external face of the guide means and said guide piece has, in its external face, retractable tongues capable of interacting with said lips, whereby said seal is prevented from leaving said guide piece.

17. Syringe device according to claim 16, wherein said ring comprises three sealing lips and, in the storage position, said tongues are arranged between the outermost lip and the intermediate lip.

18. Syringe device according to claim 1, wherein the guide means furthermore include second sealing means capable of providing, with the first sealing means, confinement of the communication means inside said guide means.

19. Syringe device according to claim 18, wherein said second sealing means cover the portion of the stopper of said vial intended to be perforated by the communication means.

20. Syringe device according to claim 19, wherein said first end of the guide means includes a collar capable of bearing on the opening of said vial, and means of fastening on said vial, said collar including, in its face turned towards the vial, a projecting annular portion for interacting in leaktight manner with the stopper of said vial.

21. The syringe device according to claim 1, wherein said annular seal comprises a seal having the shape of an annular ring linked in translation with the syringe in the insertion direction, said ring having, on its external face, sealing lips interacting with the internal face of the guide means and with said guide means are provided, in its external face, retractable tongues capable of interacting with said lips, whereby said seal is prevented from leaving said guide means.

22. Syringe device according to claim 21, wherein said ring comprises three sealing lips and in the storage position, said tongues are arranged between the outermost lip and the intermediate lip.

23. The syringe device according to claim 1, wherein said annular seal comprises an annular ring linked in translation with the syringe in the insertion direction, said ring having, on its internal and external faces, sealing lips, and said guide piece includes shoulder means to prevent said seal from leaving said guide means.

25. The syringe device according to claim 1, wherein said annular seal comprises an annular ring linked in translation with the syringe in the insertion direction, said ring having, on its internal and external faces, sealing lips, and said guide piece includes a shoulder to prevent said seal from leaving said guide piece.

24. A syringe device making it possible to mix two compounds, at least the first of which is liquid, comprising:

a syringe provided with an injection end, the syringe adapted to contain said first compound;

means for guiding the injection end of said syringe in translation between a first withdrawn storage position and a second inserted active position, said guide means including a first end emerging opposite the perforable zone of a stopper capable of closing in leaktight manner the opening of a vial intended to contain the other compound and a second end for receiving the injection end of said syringe, said second end comprising means for providing sufficient linkage between said syringe and said guide means while allowing said translation;

an annular seal having an inner face sealingly facing the external face of the syringe body and an outer face provided with at least one sealing lip for cooperating with the inner face of said guide means, said annular seal being located close to the second end of the guide means when the syringe is in its first position, said syringe body being provided with a shoulder for moving said annular seal when said syringe body is moved from the first position to the second position; and

communication means for allowing perforation of said stopper and communication of the internal volume of said syringe with the inside of said vial when the injection end of said syringe is brought into its second position.

26. The syringe device according to claim 24, wherein said annular seal forms an integral part of the body of the syringe.

27. Syringe device according to claim 26, wherein the body of the syringe is made of plastic and said first sealing means consist of at least one annular lip projecting from the body ofthe syringe and interacting with the internal face of the guide means.

28. Syringe device according to claim 26, wherein the syringe consists of a carpule extended by a plastic adapter, at the end of which a needle is mounted, said adapter having, on its external face, at least one annular rib interacting with the internal face of the guide means, said rib constituting said first sealing means.

29. Syringe device according to claim 28, wherein said needle is screwed onto said adapter, the head of said needle being provided with radial ribs capable of interacting with a portion forming a projection into the guide piece, by which rotation of the syringe body allows unscrewing of said needle with respect to the adapter.

30. Syringe device according to claim 24, wherein said seal has the form of a ring whose face which cooperates with the body of the syringe includes at least two sealing lips.

31. Syringe device according to claim 24, wherein said seal is made of elastomer.

32. Syringe device according to claim 24, wherein said seal is made of plastic.

33. The syringe device according to claim 24, wherein said seal comprises temporary means for translational linking with the body of said syringe when said syringe is displaced between its first position and its second position.

34. Syringe device according to claim 33, wherein said temporary linking means comprise a shoulder made on the face of the seal interacting with a relief of the body of the syringe, by which said seal is moved along when the syringe body is inserted.

35. The syringe device according to claim 33, wherein said shoulder provides sealing between said seal and said syringe body.

36. The syringe device according to claim 33, wherein said seal includes a first locking element capable of interacting with a second locking element when said seal is in its second position.

37. The syringe device according to claim 33, wherein the face of said seal interacting with the guide means includes at least two sealing lips.

38. The syringe device according to claim 24, wherein the communication means comprise a needle mounted at the injection end of the syringe and whose tip is capable of perforating the central zone of the stopper when the end of the syringe is brought into its second position.

39. The syringe device according to claim 24, wherein said stopper is preperforated.

40. The syringe device according to claim 24, wherein said seal is capable of providing said sealing during the relative displacement of said syringe with respect to the guide means.

41. The syringe device according to claim 24, wherein said seal is made of elastomer.

42. The syringe device according to claim 24, wherein said seal is made of plastic.

43. The syringe device according to claim 24, wherein the guide means further includes second sealing means capable of providing, with the annular seal, confinement of the communication means inside said guide means.

44. The syringe device according to claim 43, wherein said second sealing means cover the portion of the stopper of said vial intended to be perforated by the communication means.

45. The syringe device according to claim 43, wherein said first end of the guide means includes a collar capable of bearing on the opening of said vial, and means of fastening on said vial, said collar including, in its face turned towards the vial, a projecting annular portion for interacting in leaktight manner with the stopper of said vial.

46. The syringe device according to claim 24, wherein said guide means internally comprise a perforable, elastic, leaktight membrane arranged between the first end and the second end of said guide means, said membrane being passed through, when the device is in its storage position, by said communication means, whereby the zone located between said membrane and said stoppers forms retention chamber making it possible to collect the gases which may leave said vial.

47. The syringe device according to claim 24, wherein said guide means further includes, between their first end and their second end, an orifice closed by a micropore filter.

48. The syringe device according to claim 24, wherein said guide means includes, in proximity to its first end, a piece made of porous material, passed through by said needle and capable of absorbing possible gases leaving said vial during the extraction of the needle therefrom.

49. The syringe, device according to claim 24, wherein said first end of the guide means is extended by a housing connected to the inside of the guide by a passage for passage of the needle, the free edge of said housing being applied against the stopper of said vial, whereby said housing forms a retention chamber for the gases which may leave said vial.

50. The syringe device according to claim 24, further comprising a control rod for a plunger of the syringe, said rod being screwable into said plunger.

51. The syringe device according to claim 24, further comprising an automatic injection device mountable on the assembly consisting of said syringe and said guide means after separation of said vial, said automatic injection device comprising a support for the guide means on said support, first pusher means for causing insertion of the body of the syringe with respect to said guide means by a first predetermined distance and second pusher means for causing insertion of said plunger with respect to the body of said syringe by a second predetermined distance, without altering the relative position of the syringe and of the guide means, said first end of the guide means forming a zone for bearing on the body of the patient.

52. The syringe device according to claim 24, comprising exit means for controlling the syringe outside said guide means including means for allowing the exit of the syringe from the guide means only in part such that the communication means remain in said guide means, and means allowing the complete exit of the syringe only once a rotation movement has been imparted to the syringe with respect to said guide means.