CCK antibodies used to improve feed efficiency

• US 5,827,517 A
• Filed: 02/28/1997
• Issued: 10/27/1998
• Est. Priority Date: 08/05/1994
• Status: Expired due to Term

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Cook, Mark E., Miller, Cheryl C., Pimentel, Julio L.
• Primary Examiner(s): HUFF, SHEELA JITENDRA
• Application Number:
  US08/807,435
• Time in Patent Office: 606 Days
• Field of Search: 514/12-16, 530/311, 530/324-328, 530/387.1, 530/387.9, 530/388.24, 530/389.2, 424/130.1, 424/139.1, 424/145.1, 424/184.1, 424/185.1, 424/198.1, 424/195.11
• US Class Current: 424/139.1
• CPC Class Codes: A23K 20/147 Polymeric derivatives, e.g. peptides or proteins
• CPC Class Codes: A23K 50/75 for poultry
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: C07K 16/02 from eggs
• CPC Class Codes: C07K 16/18 against material from animals or humans
• CPC Class Codes: C07K 16/26 against hormones ; against hormone releasing or inhibiting factors
• CPC Class Codes: C07K 2317/11 isolated from eggs

Abstract

A method of increasing food efficiency in both avians and mammals by using antibodies to gut peptides such as choleocystokinin to elicit a biological response which decreases gastrointestinal motility, reduces satiety or improves feed efficiency.

Claims

1. A method of modulating feeding behavior in animals, comprising the step of feeding an antibody to a gut peptide to an animal by oral administration in order to alter a physiological effect of said peptide relating to feeding or growth behavior.

2. The method of claim 1 wherein said gut peptide is choleocystokinin.

3. The method of claim 2 wherein said choleocystokinin is purified choleocystokinin peptide.

4. The method of claim 2 wherein said choleocystokinin is synthetic choleocystokinin peptide.

5. The method of claim 2 wherein said choleocystokinin is sulfated.

6. The method of claim 2 wherein said choleocystokinin is an amide.

7. The method of claim 1 wherein said gut peptide is bombesin.

8. The method of claim 1 wherein said gut peptide is neuropeptide Y.

9. The method of claim 1 wherein said gut peptide is gastrin.

10. The method of claim 1 wherein said gut peptide is somatostatin.

11. The method of claim 1 wherein said animal is an avian.

12. The method of claim 4 wherein said avian is a chicken.

13. The method of claim 1 wherein said animal is a mammal.

14. The method of claim 13 wherein said mammal is selected from the group consisting of a porcine, a bovid, an ovine, a caprine, a rodentia and a homo sapien.

15. A method of modulating feeding behavior in animals, comprising the steps of:

immunizing a producer animal with a gut peptide so that said producer animal produces an antibody to said gut peptide;

isolating a substance containing said gut peptide antibody from said producer animal; and

feeding said substance containing said gut peptide antibody to an animal by oral administration.

16. The method of claim 15 wherein said gut peptide is choleocystokinin.

17. The method of claim 15 wherein said gut peptide is bombesin.

18. The method of claim 15 wherein said gut peptide is neuropeptide Y.

19. The method of claim 15 wherein said gut peptide is gastrin.

20. The method of claim 15 wherein said gut peptide is somatostatin.

21. The method of claim 16 wherein said choleocystokinin is conjugated to a carrier protein.

22. The method of claim 21 wherein said carrier protein is keyhole limpet hemocyanin.

23. The method of claim 21 wherein said carrier protein is bovine gamma globulin.

24. The method of claim 15 wherein said substance containing said gut peptide antibody is selected from the group consisting of milk, whole egg and egg yolk.

25. The method of claim 15 wherein said substance containing said gut peptide antibody is selected from the group consisting of whole blood, blood serum and blood plasma.

26. The method of claim 15 further including the steps of separating the gut peptide antibody from said substance, and thereafter feeding said gut peptide antibody to said animal.

27. The method of claim 15 wherein said animal is selected from the group consisting of an avian, a porcine, a bovine, an ovine, a caprine, a rodentia and a homo sapien.