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Liposomes containing active agents aggregated with lipid surfactants

  • US 5,827,533 A
  • Filed: 02/06/1997
  • Issued: 10/27/1998
  • Est. Priority Date: 02/06/1997
  • Status: Expired due to Term
First Claim
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1. A liposome containing an active agent, comprising:

  • a liposome having a lipid bilayer membrane comprising vesicle-forming phospholipid and cholesterol, where the combination of phospholipid and cholesterol is the primary lipid source in the membrane, said lipid bilayer membrane containing from 3 mole percent to 60 mole percent cholesterol; and

    an active agent aggregated with lipid surfactant to form micelles said micelles entrapped within the interior space of the liposome;

    wherein said cholesterol inhibits fusion of the liposome membrane with the micelles entrapped therein, compared to fusion that would occur in the absence of cholesterol.

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