Stimulating the differentiation of predipocytic cells and therapies based thereon
First Claim
1. A regimen for treating an insulin-resistant state in a mammalian organism in need of such treatment, comprising administering to such organism a therapeutically effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, and (b) at least one fatty acid.
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Abstract
The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-α receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
97 Citations
23 Claims
- 1. A regimen for treating an insulin-resistant state in a mammalian organism in need of such treatment, comprising administering to such organism a therapeutically effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, and (b) at least one fatty acid.
- 7. A regimen for treating an insulin-resistant state in a mammalian organism in need of such treatment, comprising administering to such organism a therapeutically effective amount of a composition of matter suited for the differentiation of preadipocytic cells into adipocytic cells comprising (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, and (b) at least one fatty acid.
Specification