Intravitreal medicine delivery

• US 5,830,173 A
• Filed: 08/01/1997
• Issued: 11/03/1998
• Est. Priority Date: 12/12/1994
• Status: Expired due to Term

• Current Assignee: Robert L. Avery
• Original Assignee: Jeffrey Kevin Luttrull, Robert Logan Avery
• Inventors: Luttrull, Jeffrey Kevin, Avery, Robert Logan
• Primary Examiner(s): Weiss, John G.
• Assistant Examiner(s): RUHL, DENNIS WILLIAM
• Application Number:
  US08/904,821
• Time in Patent Office: 459 Days
• Field of Search: 604/8-10, 604/294, 424/427
• US Class Current: 604/9
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61M 2210/0612 Eyes

Abstract

An intravitreal medicine delivery device and method that includes an implant device through which a wide variety of beneficial medicines including drugs or other pharmacological agents can be introduced into the vitreous cavity over an extended period of time with only a single initial surgery to implant the device. The device and method minimize the surgical incision needed for implantation and avoid future or repeated invasive surgery or procedures. Additional amounts of the initial medicine can readily be introduced or the medication can be varied or changed, as required. Furthermore, the device and method allow the dosage delivered to the vitreous cavity to be controlled, and the device is constructed so as to filter medicines delivered to the cavity and also avoids damage to or interference with other parts of the eye during implantation or during use.

Claims

1. A method of delivering medicine to the vitreous cavity of the eye comprising the steps of:

establishing a reservoir on the eyewall and under the conjunctiva for holding a supply of a medicine, and

providing a passageway between the reservoir and the vitreous cavity and through which medicine can move from the reservoir into the cavity, said passageway also being provided under the conjunctiva so that the entire reservoir and passageway are under the conjunctiva.

2. The method of claim 1 including the further step of intermittently introducing medicine into the reservoir while the reservoir remains on the eyeball.

3. The method of claim 2 wherein the intermittent introduction of medicine involves the further step of introducing a quantity of medicine into the reservoir greater than a predetermined single dose thereof, and including the further step of enabling such a predetermined dose of medicine to move into the vitreal cavity at selected intervals between said intermittent introductions of medicine into the reservoir.

4. The method of claim 2 wherein said intermittent introducing step involves the further steps of introducing selectively different types of medicines into the reservoir at different times without removing the reservoir from the eyewall.

5. The method of claim 1 including the further step of restricting passage of medicine from the reservoir into the vitreous cavity while medicine is being introduced into the reservoir.

6. The method of claim 1 wherein the establishing step involves suturing an intravitreal medicine delivery device which includes the reservoir and the injection port on the eyewall under the conjunctiva and Tenon'"'"'s capsule, said device including fluid conducting means and pump means actuatable from externally of the eye, said conducting means having a proximate end connected to the reservoir and a distal end, and wherein the enabling step involves inserting the distal end into the vitreal cavity and subsequently actuating said pump means from externally of the eye to pump fluid from the reservoir into the vitreal cavity.

7. A method of delivering medicine including drugs and other pharmacological agents to the vitreous cavity of the eye involving the use of an implant device which has a reservoir with a reservoir-refilling injection port comprising the steps of

implanting the reservoir including the injection port under the conjunctiva and Tenon'"'"'s capsule of the eye so that the injection port faces anteriorly of the eye and can be seen exteriorly of the eye through the conjunctiva,

establishing a connection between the reservoir and the vitreous cavity which allows passage of medicine from the reservoir into the vitreous cavity, and

introducing medicine into the reservoir by injection through the port.

8. A method of delivering medicine to the vitreous cavity of the eye comprising the steps of:

establishing a reservoir on the eyewall for holding a supply of a medicine,

providing a passageway between the reservoir and the vitreous cavity through which medicine can move from the reservoir into the cavity,

wherein the establishing step involves suturing an intravitreal medicine delivery device which includes the reservoir on the eyewall under the conjunctiva and Tenon'"'"'s capsule, said device including fluid conducting means and pump means actuatable from externally of the eye, said conducting means having a proximate end connected to the reservoir and a distal end, and wherein the enabling step involves inserting the distal end into the vitreal cavity and subsequently actuating said pump means from externally of the eye to pump fluid from the reservoir into the vitreal cavity, and

wherein the fluid conducting means includes a resiliently compressible portion which functions as the pump and is actuatable by pressing against the compressible portion, wherein the suturing step involves locating the compressible portion under the eyelid, and wherein said actuating step involves pressing against the compressible portion through the eyelid.