Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide
First Claim
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1. A method for intra-vascular delivery to a mammal of an embolic composition while inhibiting vasospasms in the mammal which method comprises:
- (a) selecting an embolic composition comprising a biocompatible, water insoluble polymer and an embolic solvent; and
(b) intra-vascularly injecting the composition selected in (a) above into the mammal at a flow rate such that the concentration of the embolic solvent in a given blood volume is maintained at a level insufficient to initiate vasospasms.
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Abstract
Disclosed are novel methods for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery of an embolic composition comprising a biocompatible polymer and an embolic solvent.
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17 Claims
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1. A method for intra-vascular delivery to a mammal of an embolic composition while inhibiting vasospasms in the mammal which method comprises:
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(a) selecting an embolic composition comprising a biocompatible, water insoluble polymer and an embolic solvent; and (b) intra-vascularly injecting the composition selected in (a) above into the mammal at a flow rate such that the concentration of the embolic solvent in a given blood volume is maintained at a level insufficient to initiate vasospasms. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for the catheter delivery of an embolic composition comprising a biocompatible polymer, a water insoluble biocompatible contrast agent, and an embolic solvent to an intra-vascular injection site of a mammal which method comprises:
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(a) select a microcatheter comprising a luer hub and a delivery means; (b) insert the delivery means of the microcatheter selected in (a) above into a to-be-embolized vascular site of a mammal and confirming placement in vivo with a water soluble contrast agent; (c) connect a syringe to the microcatheter luer hub and flushing any remaining water soluble contrast agent from the microcathether hub and delivery means with a solution comprising water; (d) add at least 0.50 cc of the embolic solvent to a second syringe; (e) attach the second syringe prepared in (d) above to the microcatheter luer hub and then inject no more than about 0.3 cc of the embolic solvent into vascular site to flush out the aqueous contrast agent; (f) remove the second syringe from the luer hub and then overfill/wash the luer hub of the microcatheter with the balance of the embolic solvent; (g) connect a syringe comprising an embolic composition to the microcatheter hub while ensuring that air does not enter into the hub during connection wherein the embolic composition comprises an embolic solvent, a biocompatible polymer dissolved in the solvent, and a water insoluble biocompatible contrast agent dispersed therein; (h) create a sharp interfacial boundary between the embolic solvent and the embolic composition; (i) inject over about a 1 minute period sufficient amount of the solution to displace the DMSO in the microcatheter; and (j) inject the embolic composition into the vascular site at a flow rate such that the concentration of the embolic solvent in a given blood volume is maintained at a level which inhibits vasospasms. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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Specification