Electromagnetically triggered, responsive gel based drug delivery device

• US 5,830,207 A
• Filed: 01/30/1997
• Issued: 11/03/1998
• Est. Priority Date: 02/24/1995
• Status: Expired due to Fees

• Current Assignee: Advanced Medical Solutions (Plymouth) Ltd.
• Original Assignee: Medlogic Global Corp. (Advanced Medical Solutions Group Plc)
• Inventors: Hovorka, George, Leeb, Steven B., Yu, Xiaohong, Lupton, Elmer C.
• Primary Examiner(s): Lacyk, John P.
• Assistant Examiner(s): GILBERT, SAMUEL G
• Application Number:
  US08/791,368
• Time in Patent Office: 642 Days
• Field of Search: 604/890.1, 604/891.1, 604/49, 604/131, 604/246, 128/899, 600/9-14
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097

Abstract

A system for remotely inducing a phase transition in a gel is provided. The system includes a gel capable of volume change in response to an environmental stimulus, a seed material in contact with the gel, and generating a time-varying magnetic or a time-varying electric or electromagnetic field in the proximity of the gel to produce the environmental stimulus. In a preferred embodiment, the environmental stimulus is temperature.

Claims

1. A system for remotely inducing a phase transition in a gel, comprising:

a gel comprising a cross-linked network of polymers swollen in solvent which gel is capable of a phase transition in response to an environmental stimulus;

a magnetic or electromagnetic receptor in contact with said gel; and

means for generating a time-varying magnetic field or an electromagnetic field, respectively, in proximity of said gel to produce said environmental stimulus.

2. The system of claim 1, wherein the environmental stimulus comprises a change in temperature.

3. The system of claim 1, wherein the gel phase transition results in release from the gel of a biologically active compound.

4. The system of claim 1, wherein the magnetic receptor has a long dimension and is oriented to optimize the generation of the environmental stimulus.

5. The system of claim 1, wherein said time-varying magnetic field comprises a quasi-static magnetic field.

6. The system of claim 1, wherein said magnetic receptor comprises a ferromagnetic receptor.

7. The system of claim 1, wherein said magnetic receptor comprises an iron-containing derivative.

8. The system of claim 1, wherein said magnetic receptor comprises a material selected from the group consisting of iron, cobalt, nickel, steel, iron oxide, and transition metal ferrites.

9. The system of claim 1, wherein said magnetic receptor is in the form selected from the group consisting of film, rod, particle, fluid, glass-encased particle and bead.

10. The system of claim 1, wherein the gel is a hydrogel.

11. The system of claim 1, wherein the gel is swollen by an is organic solvent.

12. A method of remotely inducing a phase transition in a gel, comprising:

selecting a gel comprising a cross-linked network of polymers swollen in solvent which gel is capable of a phase transition in response to an environmental stimulus, said gel is placed in contact with a magnetic receptor; and

applying a time-varying magnetic field in proximity of said gel, said magnetic field generating a response in said magnetic receptor, thereby providing the environmental stimulus which induces said gel to undergo a phase transition.

13. The method of claim 12, wherein the step of applying a time-varying magnetic field comprises applying a quasi-static magnetic field.

14. The method of claim 12, wherein the gel is responsive to a change in temperature.

15. The method of claim 12, wherein application of the time-varying magnetic field induces a phase transition in the gel which results in release from the gel of a biologically active compound.

16. The method of claim 12, wherein the gel selected therein is a hydrogel.