Method of treatment using a therapeutic combination of .alpha. interferon and free radical scavengers

• US 5,830,455 A
• Filed: 09/06/1996
• Issued: 11/03/1998
• Est. Priority Date: 12/22/1992
• Status: Expired due to Fees

• Current Assignee: Glaxo Wellcome Incorporated (GSK plc)
• Original Assignee: Glaxo Wellcome Incorporated (GSK plc)
• Inventors: Ruiz, Oscar Beloqui, Valtuena, Jesus Prieto
• Primary Examiner(s): Sayala, Chhaya D.
• Application Number:
  US08/706,645
• Time in Patent Office: 788 Days
• Field of Search: 424/85.4, 424/85.7, 514/18
• US Class Current: 424/85.4
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 17/32075 Pullback cutting; combined forward and pullback cutting, e.g. with cutters at both sides of the plaque
• CPC Class Codes: A61B 17/3211 Surgical scalpels, knives; Accessories therefor
• CPC Class Codes: A61B 17/3417 Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating syringe needles A61M5/32; dilators A61M29/00
• CPC Class Codes: A61B 17/3474 Insufflating needles, e.g. Veress needles
• CPC Class Codes: A61B 17/3476 Powered trocars, e.g. electrosurgical cutting, lasers, powered knives
• CPC Class Codes: A61B 17/3496 Protecting sleeves or inner probes; Retractable tips for protecting body piercing guide needles A61M25/0612
• CPC Class Codes: A61B 18/1487 Trocar-like, i.e. devices producing an enlarged transcutaneous opening
• CPC Class Codes: A61B 2018/0019 vibrating
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 38/06 Tripeptides
• CPC Class Codes: A61K 38/063 Glutathione
• CPC Class Codes: A61K 38/21 Interferons [IFN]
• CPC Class Codes: A61K 38/212 IFN-alpha
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 13/003 Blowing gases other than for carrying powders, e.g. for inflating, dilating or rinsing
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to a therapeutic combination therapy involving the use of human interferon. The therapy involves the treatment of conditions susceptible to treatment with human interferon, with a combination of a human interferon and a free radical scavenger or precursor or inducer.

Claims

1. A method for the treatment of a patient suffering from chronic hepatitis C infection with a human interferon-α

who has failed to respond to treatment with the human interferon-α

which comprises treatment of the patient with effective amounts of the human interferon-α and

a free radical scavenger or precursor or inducer thereof.

2. A method according to claim 1, wherein the human interferon-α

is recombinant.

3. A method according to claim 1, wherein the human interferon-α

is natural.

4. A method according to claim 3, wherein the natural human interferon-α

is human lymphoblastoid interferon.

5. A method according to claims 1, 2, 3 or 4, wherein the free radical scavenger or precursor or inducer thereof is glutathione or a precursor or inducer thereof.

6. A method according to claims 1, 2, 3 or 4, wherein the free radical scavenger or precursor or inducer thereof is N-acetyl cysteine.

7. A method according to claim 1, wherein the patient has previously responded to treatment with the human interferon.