Dosage form comprising hydrophilic polymer
First Claim
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1. A dosage form for administering a drug to a patient, wherein the dosage form comprises:
- (1) a wall comprising a semipermeable composition, which wall defines a compartment;
(2) 10 ng to 1200 mg of drug in the compartment;
(3) a push composition in the compartment for pushing the drug from the dosage form;
(4) at least one exit port in the dosage form for delivering the drug from the dosage form; and
wherein the dosage form is characterized by the compartment comprising;
(5) 15 wt % to 60 wt % of a hydrophilic polymer that precipitates in situ in the presence of fluid that enters the compartment and means for causing the hydrophilic polymer to precipitate comprising the drug whereby the dosage form, administers the drug to the patient.
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Abstract
A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
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Citations
1 Claim
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1. A dosage form for administering a drug to a patient, wherein the dosage form comprises:
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(1) a wall comprising a semipermeable composition, which wall defines a compartment; (2) 10 ng to 1200 mg of drug in the compartment; (3) a push composition in the compartment for pushing the drug from the dosage form; (4) at least one exit port in the dosage form for delivering the drug from the dosage form; and
wherein the dosage form is characterized by the compartment comprising;(5) 15 wt % to 60 wt % of a hydrophilic polymer that precipitates in situ in the presence of fluid that enters the compartment and means for causing the hydrophilic polymer to precipitate comprising the drug whereby the dosage form, administers the drug to the patient.
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Specification
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Current AssigneeALZA Corporation (Johnson & Johnson)
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Original AssigneeALZA Corporation (Johnson & Johnson)
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InventorsBurkoth, Terry L., Dong, Liang C., Wong, Patrick S. -L., Barclay, Brian L., Childers, Jerry D., Dealey, Michael H.
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Primary Examiner(s)BROUILLETTE, D GABRIELLE
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Application NumberUS07/964,548Time in Patent Office2,204 DaysField of Search424/473, 424/472US Class Current424/473CPC Class CodesA61K 9/0004 Osmotic delivery systems; S...
