Solid dosage forms

• US 5,830,576 A
• Filed: 05/23/1997
• Issued: 11/03/1998
• Est. Priority Date: 01/16/1991
• Status: Expired due to Fees

• Current Assignee: FMC Corporation
• Original Assignee: FMC Corporation
• Inventors: Ibrahim, Nagui I., Fleck, Edwin G. Jr., Mehra, Dev K.
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US08/874,203
• Time in Patent Office: 529 Days
• Field of Search: 424/464, 424/465-470, 424/452, 424/489, 424/417, 424/421, 424/408, 504/100, 504/101
• US Class Current: 424/408
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623

Abstract

A composition for agricultural and other actives, comprising a finely-divided particulate combination of microcrystalline cellulose, at least one nitrogen compound such as urea, an ammonium sulfate or phosphate and, optionally, a suspending agent for the micro-crystalline cellulose. The composition can be compacted to form shaped, solid dosage forms such as tablets which disintegrate rapidly in an aqueous medium.

Claims

1. A compression moldable finely divided homogeneous particulate excipient blend for producing compacted solid dosage forms, consisting essentially of microcrystalline cellulose having a particle size from about 20 to about 90 microns and a nitrogen compound selected from the group consisting of urea, ammonium sulfate and ammonium phosphate, in which the weight ratio of microcrystalline cellulose to nitrogen compound is from 2:

1 to about 1;

3, said composition optionally containing from 0.5 to 25% by weight, based on the microcrystalline cellulose, of a suspending agent selected from water soluble hydrocolloids compatible with and effective for assisting in the hydration of microcrystalline cellulose.

2. The composition according to claim 1 wherein the nitrogen compound comprises urea.

3. The composition according to claim 1 wherein the suspending agent comprises sodium carboxymethylcellulose.

4. The composition of claim 1 in which the particulate excipient blend is produced by spray drying an aqueous homogeneous slurry of microcrystalline cellulose and urea.

5. The composition of claim 4 including from 0.5 to 25 percent by weight, based on the microcrystalline cellulose, of a suspending agent comprising sodium carboxymethylcellulose.