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Neural thread protein gene expression and detection of Alzheimer's disease

  • US 5,830,670 A
  • Filed: 05/30/1995
  • Issued: 11/03/1998
  • Est. Priority Date: 12/21/1988
  • Status: Expired due to Term
First Claim
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1. A method of diagnosing the presence of Alzheimer'"'"'s Disease in a human subject suspected of having Alzheimer'"'"'s Disease which comprises:

  • (a) incubating a biological sample from said subject which is suspected of containing neural thread protein (NTP) having a molecular weight observed by SDS-PAGE of about 8 kDa, about 14 kDa, about 17 kDa, about 21 kDa, about 26 kDa or about 42 kDa, in the presence of at least one antibody that specifically binds said NTP and does not cross-react with pancreatic thread protein; and

    (b) detecting said antibody which is bound in said sample, wherein detection of elevated levels of NTP indicates that said subject has Alzheimer'"'"'s Disease.

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