Methods of creating a unique chitosan and employing the same to form complexes with drugs, delivery of the same within a patient and a related dosage form

• US 5,830,883 A
• Filed: 11/06/1995
• Issued: 11/03/1998
• Est. Priority Date: 11/06/1995
• Status: Expired due to Term

• Current Assignee: Dequesne University of The Holy Spirit, Lawrence H. Block
• Original Assignee: Duquesne University of The Holy Ghost
• Inventors: Sabnis, Shobhan S., Block, Lawrence H.
• Primary Examiner(s): FONDA, KATHLEEN KAHLER
• Application Number:
  US08/544,428
• Time in Patent Office: 1,093 Days
• Field of Search: 514/55, 604/890.1, 604/891.1, 424/422, 424/423, 424/424, 424/425
• US Class Current: 514/55
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L

Abstract

A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3.5 kDa to 250 kDa and preferably about 3.5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization. The layer of the chitosan-drug complex is characterized by a prolonged drug time release property as compared with complexes made from polymerized chitosan. A corresponding method of providing drug delivery to the locale of the implant within a patient is disclosed as is the implant.

Claims

1. A method of making a time release drug delivering implant comprising

providing an implant,

creating a complex of depolymerized chitosan and a drug by ionically bonding said chitosan and drug, and

establishing a layer of said chitosan-drug complex on at least a portion of said implant.

2. The method of claim 1 including establishing said layer by coating at least a portion of said implant.

3. The method of claim 1 including establishing said layer by applying a film containing said chitosan-drug complex to said implant.

4. The method of claim 1 including employing an antibiotic as said drug.

5. The method of claim 1 including employing an anti-inflammatory as said drug.

6. The method of claim 1 including employing as said chitosan a chitosan having a molecular weight of about 3.5 kDa to 250 kDa.

7. The method of claim 1 including employing as said chitosan a chitosan having a molecular weight of about 3.5 kDa to 75 kDa.

8. The method of claim 1 including establishing said layer by self-adhering said layer to said implant.

9. The method of claim 1 including prior to depolymerizing said chitosan, deacetylating said chitosan by at least 60 percent.

10. The method of claim 7 including prior to depolymerizing said chitosan, deacetylating said chitosan by at least 70 percent.

11. The method of claim 9 including applying said chitosan-drug layer in an average thickness of about 0.01 to 0.30 cm.

12. The method of claim 1 including establishing by said layer longer time release properties of said drug as compared with polymerized chitosan-drug complexes.

13. The method of claim 1 including employing said chitosan in microcrystalline powder form.

14. The method of claim 12 including said portion of said implant including an external surface thereof.

15. The method of claim 6 including prior to depolymerizing said chitosan, deacetylating said chitosan by at least 70 percent.

16. The method of claim 13 including employing said microcrystalline powder in a particle size of about 75 μ

m to 425 μ

m.

17. The method of claim 1 including employing a chemical process to depolymerize said chitosan.

18. The method of claim 16 wherein said implant is a synthetic or natural body part.

19. A time release drug delivering implant comprising

an implant,

a complex of a depolymerized chitosan and a drug disposed on at least a portion of said implant, and

said complex being an ionically bonded complex.

20. The implant of claim 19 including said layer being a coating.

21. The implant of claim 19 including said layer being a film secured to at least a portion of said implant.

22. The implant of claim 19 including said drug being an antibiotic.

23. The implant of claim 19 including said drug being an anti-inflammatory agent.

24. The implant of claim 22 including said depolymerized chitosan component of said chitosan-drug complex having a molecular weight of about 3.5 kDa to 250 kDa.

25. The implant of claim 19 including said layer of said chitosan-drug being self-adhered to said implant.

26. The implant of claim 19 including said chitosan component of said chitosan-drug complex being a deacetylated chitosan.

27. The implant of claim 26 including said deacetylated chitosan being at least 60 percent deacetylated.

28. The implant of claim 27 including said chitosan-drug complex layer having a thickness of about 0.01 to 0.30 cm.

29. The implant of claim 19 including said chitosan-drug complex having longer time drug release properties as compared with a nondepolymerized chitosan-drug combination.

30. The implant of claim 19 including said depolymerized chitosan having a molecular weight of about 3.5 to 75 kDa.

31. The implant of claim 29 including said implant being an artificial organ.

32. The implant of claim 29 including said implant being a catheter.

33. The implant of claim 19 including said portion including an external surface thereof.

34. The implant of claim 31 including said chitosan being a chemically depolymerized chitosan.

35. The implant of claim 28 including said deacetylated, depolymerized chitosan having a reduced viscosity in aqueous solutions as compared with chitosans which have a greater molecular weight and are not deacetylated to the same extent.

36. A method of providing time release drug delivery to a patient at the location of an implant comprising

providing an implant,

creating a complex of a depolymerized chitosan and said drug by ionically bonding said chitosan to said drug,

establishing a layer of said chitosan-drug complex on at least a portion of said implant, and

introducing said implant into said patient.

37. The method of claim 36 including establishing said layer by coating at least a portion of said implant.

38. The method of claim 36 including establishing said layer by applying a film containing said chitosan-drug complex to said implant.

39. The method of claim 36 including employing an antibiotic as said drug.

40. The method of claim 36 including employing an anti-inflammatory as said drug.

41. The method of claim 39 including employing as said chitosan a chitosan having a molecular weight of about 3.5 kDa to 250 kDa.

42. The method of claim 36 including establishing said layer by self-adhering said layer to said implant.

43. The method of claim 36 including prior to depolymerization of said chitosan, deacetylating said chitosan by at least about 60 percent.

44. The method of claim 43 including employing as said chitosan a chitosan having a molecular weight of about 3.5 to 75 kDa.

45. The method of claim 44 including applying said chitosan-drug layer in an average thickness of about 0.20 to 0.30 cm.

46. The method of claim 36 including establishing by said layer a longer time release property of said drug as compared with nondepolymerized chitosan-drug combinations.

47. The method of claim 46 including said portion including an external surface thereof.

48. The method of claim 36 including employing a chemical process to depolymerize said chitosan.