Antibodies specific for megakaryocyte differentiation factor

• US 5,831,030 A
• Filed: 06/07/1995
• Issued: 11/03/1998
• Est. Priority Date: 07/17/1992
• Status: Expired due to Term

• Current Assignee: Asubio Pharma Co., Ltd. (Daiichi Sankyo Company Limited)
• Original Assignee: Suntory Ltd (Kotobuki Realty Co., Ltd.)
• Inventors: Ishida, Nobuhiro, Tsuruoka, Nobuo, Nakazato, Hiroshi, Miura, Kenju, Yamaguchi, Nozomi, Tsujimoto, Masafumi, Kurihara, Tatsuya, Iwasa, Fuyuki, Yamaichi, Kozo
• Primary Examiner(s): Eisenschenk, Frank C.
• Assistant Examiner(s): RABIN, EVELYN MARIE
• Application Number:
  US08/472,659
• Time in Patent Office: 1,245 Days
• Field of Search: 530/387.1, 530/387.9, 530/389.2, 530/388.243, 530/397
• US Class Current: 530/387.9
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: C07K 14/475 Growth factors; Growth regulators

Abstract

The present invention provides novel megakaryocyte differentiation factors, which are useful as therapeutic agents due to their accelerating effects on the differentiation of megakaryocytes and their thrombopoietic effects. The megakaryocyte differentiation factors of the present invention include the megakaryocyte differentiation factor having the amino acid sequence shown in SEQ ID NO: 34. The present invention also provides DNA coding for the megakaryocyte differentiation factors of the present invention, expression vectors containing the DNA, hosts transformed with the expression vectors, and processes for production of the megakaryocyte differentiation factors using transformed hosts. The present invention further provides specific antibodies to the megakaryocyte differentiation factors of the present invention.

Claims

1. An antibody which specifically binds to a megakaryocyte differentiation factor consisting of the amino acid sequence shown in SEQ ID NO:

34.

2. An antibody according to claim 1, wherein the megakaryocyte differentiation factor is glycosylated.