Process of continuous noninvasive hemometry

• US 5,833,602 A
• Filed: 10/11/1994
• Issued: 11/10/1998
• Est. Priority Date: 09/20/1993
• Status: Expired due to Fees

• Current Assignee: Omoigui Osemwota
• Original Assignee: Omoigui Osemwota
• Inventors: Osemwota, Omoigui
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US08/327,361
• Time in Patent Office: 1,491 Days
• Field of Search: 600/310, 600/322-4, 600/326, 600/328, 600/330, 600/331, 356/41
• US Class Current: 600/310
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: A61B 8/04 Measuring blood pressure

Abstract

This invention relates to a process of determining continuously and non-invasively (without the withdrawal of blood.) the concentrations of hemoglobin. This is done by measurement of the path length and analysis of the pulsatile component of absorbance of multiple wave lengths of light transmitted through a tissue bed. This invention also relates to the process of simultaneous direct or indirect measurement of the pulsatile arterial width or arterial diameter which is equivalent to the pulsatile path length of the light transmitted across the tissue bed. Measurement of this arterial diameter or pulsatile path length is a prerequisite for non invasive determination of the hemoglobin, hematocrit or pigment concentrations in blood.

Claims

1. A process to determine continuously, non-invasively a hemoglobin concentration and hematocrit by analysis of a pulsatile component of absorbance of an isobestic wavelength of light for oxygenated hemoglobin and deoxyhemoglobin comprising the following steps:

a. attaching a pressure cuff to an extremity of a patient;

b. attaching a sensor probe from an isobestic wavelength oximeter to the extremity of said patient;

c. inflating said pressure cuff above systolic arterial pressure, then deflating to determine systolic pressure;

d. repeating steps a-c to determine the maximum systolic arterial pressure;

d. determining the maximal arterial diameter from the maximum systolic arterial pressure;

e. transmitting light at a predetermined isobestic wavelength from said sensor probe across said extremity such that the light passes through both venous blood, pulsatile arterial blood, and a tissue bed in said extremity;

f. receiving light from said sensor probe that has passed through the extremity;

g. determining the AC and DC components of the received light, AC and DC;

h. determining said pulsatile component of absorbance PA of the received light which is related to the hemoglobin concentration and independent of the intensity of the received light from the formula PC=AC/DC;

i. determining the hemoglobin concentration THB using the equation;

space="preserve" listing-type="equation">THB=@PA/E*Ln;

where @ is a scalar coefficient

E is the extinction coefficient for light at the predetermined wavelength

Ln is the path length of light at the predetermined wavelength; and

j. determining hematocrit from THB.

2. A process to determine continuously, non-invasively a hemoglobin concentration and hematocrit by analysis of a pulsatile component of absorbance of an isobestic wavelength of light for oxygenated hemoglobin and deoxyhemoglobin comprising the following steps:

a. attaching an ultrasonic echo tracking device to an extremity of a patient to allow continuous, non-invasive measurement of arterial diameter;

b. attaching a sensor probe from an isobestic wavelength oximeter to said extremity of said patient;

c. generating and detecting ultrasonic pulse with said ultrasonic echo tracking device;

d. determining the maximal arterial diameter from the detected ultrasonic pulses;

e. transmitting light of a predetermined isobestic wavelength from said sensor probe across said extremity such that the light passes through both venous blood, pulsatile arterial blood, and a tissue bed in said extremity;

f. receiving light at said predetermined wavelength that has passed through the extremity using said sensor probe;

g. determining the AC and DC components of the received light, AC and DC;

h. determining said pulsatile component of absorbance PA of the received light which is related to the hemoglobin concentration and independent of the intensity of the received light from the formula PC=AC/DC;

i. determining the hemoglobin concentration THB using the equation;

space="preserve" listing-type="equation">THB=@PA/E*Ln;

where @ is a scalar coefficient

E is the extinction coefficient for light at the predetermined wavelength

Ln is the path length of light at the predetermined wavelength; and

j. determining hematocrit from THB.