Therapeutic intraluminal stents
First Claim
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1. An intraluminal stent comprising:
- a lumen-wall contacting surface;
a lumen-exposed surface;
a first polymer composition comprising fibrin, the composition covering at least a portion of the lumen-wall contacting surface of the stent; and
a virus, comprising nucleic acid, capable of delivering the nucleic acid to a cell wherein the virus is associated with the first polymer composition covering the lumen-wall contacting surface.
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Abstract
This invention relates to an intraluminal stent having a lumen-wall contacting surface and a lumen-exposed surface wherein the stent comprises a first polymer composition comprising fibrin and wherein the stent is suitable to deliver virus to the wall of a lumen of the body. The invention also relates to methods for making the stent and to methods for delivering nucleic acid to cells accessible from a wall of a body lumen.
369 Citations
30 Claims
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1. An intraluminal stent comprising:
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a lumen-wall contacting surface; a lumen-exposed surface; a first polymer composition comprising fibrin, the composition covering at least a portion of the lumen-wall contacting surface of the stent; and a virus, comprising nucleic acid, capable of delivering the nucleic acid to a cell wherein the virus is associated with the first polymer composition covering the lumen-wall contacting surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for delivering nucleic acid to cells accessible from a wall of a body lumen comprising the steps of:
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providing a stent comprising a lumen-wall contacting surface, a lumen-exposed surface, a first polymer composition comprising fibrin covering at least a portion of the lumen-wall contacting surface to form a polymer covered stent; and
virus comprising nucleic acid associated with the first polymer composition wherein the stent is capable of delivering nucleic acid to cells accessible from a wall of a body lumen;positioning the stent in a lumen of the body; and contacting the lumen-wall contacting surface of the stent with the wall of a lumen of the body. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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29. A kit comprising:
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a stent comprising a lumen-wall contacting surface, a lumen-exposed surface, and a first polymer composition comprising fibrin covering at least a portion of the lumen-wall contacting surface of the stent; a virus-loading solution to be applied to the stent; and a container to house the stent and the solution during application of the virus loading solution. - View Dependent Claims (30)
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Specification