Implantable stimulation lead having an advanceable therapeutic drug delivery system
First Claim
1. An implantable endocardial pacing lead for use with a cardiac pacemaker, the pacing lead including an electrical conductor encased in an insulation sheath extending from a proximal end to a distal end of the pacing lead and an connector affixed to said proximal end of said conductor, said pacing lead further comprising:
- an active fixation electrode assembly affixed to said distal end of said conductor, said active fixation electrode assembly being capable of axial advancement relative to the distal end of said pacing lead to penetrate myocardial tissue, said active fixation electrode assembly having an active fixation electrode; and
stabilizing means extending beyond the active fixation electrode and axially advanceable simultaneously with the advancing of said active fixation electrode assembly, for stabilizing the distal end of the pacing lead at a desired location in the myocardial tissue as the electrode penetrates into the myocardial tissue, wherein said stabilizing means comprises a biocompatible matrix material.
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Accused Products
Abstract
A pacing lead having a stylet introduced anti-inflammatory drug delivery element advanceable from the distal tip electrode. The element is preferably formed as a moldable biocompatible composite material. The element has a biocompatible matrix material which may be combined with drugs and therapeutic agents to deliver the drugs and agents by co-dissolution or diffusion to the point of either passive or active fixation. The drug delivery element may be rigid and serve to center an active fixation mechanism, preferably a helix, which penetrates the myocardium.
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Citations
33 Claims
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1. An implantable endocardial pacing lead for use with a cardiac pacemaker, the pacing lead including an electrical conductor encased in an insulation sheath extending from a proximal end to a distal end of the pacing lead and an connector affixed to said proximal end of said conductor, said pacing lead further comprising:
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an active fixation electrode assembly affixed to said distal end of said conductor, said active fixation electrode assembly being capable of axial advancement relative to the distal end of said pacing lead to penetrate myocardial tissue, said active fixation electrode assembly having an active fixation electrode; and stabilizing means extending beyond the active fixation electrode and axially advanceable simultaneously with the advancing of said active fixation electrode assembly, for stabilizing the distal end of the pacing lead at a desired location in the myocardial tissue as the electrode penetrates into the myocardial tissue, wherein said stabilizing means comprises a biocompatible matrix material. - View Dependent Claims (2, 3)
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4. An implantable endocardial pacing lead for use with a cardiac pacemaker, the pacing lead including an electrical conductor encased in an insulation sheath extending from a proximal end to a distal end of the pacing lead and an electrical connector affixed to said proximal end of said conductor, said pacing lead further comprising:
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an active fixation electrode assembly affixed to said distal end of said conductor, said active fixation electrode assembly being capable of axial advancement relative to the distal end of said pacing lead to penetrate myocardial tissue, said active fixation electrode assembly having an active fixation electrode; and stabilizing means extending beyond the active fixation electrode and axially advanceable simultaneously with the advancing of said active fixation electrode assembly, for stabilizing the distal end of the pacing lead as the electrode penetrates into the myocardial tissue, wherein said stabilizing means comprises therapeutic delivery means. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. An implantable endocardial pacing lead for use with a cardiac pacemaker, the pacing lead including an electrical conductor encased in an insulation sheath extending from a proximal end to a distal end of the pacing lead and an electrical connector affixed to said proximal end of said conductor, said pacing lead further comprising:
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an active fixation electrode assembly affixed to said distal end of said conductor, said active fixation electrode assembly being capable of axial advancement relative to the distal end of said pacing lead to penetrate myocardial tissue, said active fixation electrode assembly having an active fixation electrode in the form of a rigid helix rotatable into myocardial tissue; and stabilizing means extending beyond the active fixation electrode and axially advanceable simultaneously with the advancing of said active fixation electrode assembly, for providing an axis about which the rigid helix is rotatable thereby stabilizing the distal end of the pacing lead as the active fixation electrode penetrates and then rotates about said axis into the myocardial tissue, wherein said stabilizing means comprises therapeutic delivery means.
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Specification