Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core
First Claim
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1. A method of forming an implantable and retrievable immunoisolatory vehicle, the method comprising the steps of:
- (a) forming a jacket of biocompatible thermoplastic or hydrogel, and(b) loading said jacket with a core comprising a volume of at least 1 μ
l and at least 104 cells capable of secreting a biologically active product or biocompatible matrix comprising a hydrogel, said jacket having a molecular weight cutoff permitting passage of molecules thereacross to provide said biologically active product of said function.
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Abstract
A method of forming an implantable and retrievable immunoisolatory vehicle is disclosed, the method comprising the steps of first forming a jacket of biocompatible thermoplastic or hydrogel, and then loading the jacket with a core comprising a volume of at least 1 μl and at least 104 cells capable of secreting a biocompatible matrix comprising a hydrogel or extracellular matrix, said jacket having a molecular weight cutoff permitting passage of molecules thereacross to provide said biologically active product or said function.
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Citations
25 Claims
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1. A method of forming an implantable and retrievable immunoisolatory vehicle, the method comprising the steps of:
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(a) forming a jacket of biocompatible thermoplastic or hydrogel, and (b) loading said jacket with a core comprising a volume of at least 1 μ
l and at least 104 cells capable of secreting a biologically active product or biocompatible matrix comprising a hydrogel, said jacket having a molecular weight cutoff permitting passage of molecules thereacross to provide said biologically active product of said function. - View Dependent Claims (2, 3, 4, 10, 11, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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5. A method of forming an implantable and retrievable immunoisolatory vehicle, the method comprising the steps of:
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(a) forming a jacket of biocompatible thermoplastic or hydrogel, and (b) loading said jacket with a core comprising a volume of at least 1 μ
l and at least 104 cells capable of secreting a biologically active product or providing a metabolic or immunologic function, said cells being dispersed in a biocompatible matrix comprising extracellular matrix components, said jacket having a molecular weight cutoff permitting passage of molecules thereacross to provide said biologically active product or said function. - View Dependent Claims (6, 7, 8, 9, 12, 13)
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Specification