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Bioartificial devices and cellular matrices therefor

  • US 5,834,005 A
  • Filed: 12/07/1995
  • Issued: 11/10/1998
  • Est. Priority Date: 02/24/1992
  • Status: Expired due to Term
First Claim
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1. A bioartificial implantable device comprising capsule means, a hydrogel matrix containing a cellular moiety releasing a therapeutically desirable entity, said matrix comprising gelatin in a concentration of about 0.01 to 30 mM, a liquid in an amount of about 15 to 96.5 percent by weight, and a nitric oxide inhibitor in the concentration of about 0.001 to 300 mM, and a semi-permeable membrane vacuum deposited over said capsule means, said membrane comprising poly-para-xylylene having a molecular weight porosity between the molecular weight of said entity and about 40,000.

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