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Dendrimeric compounds

  • US 5,834,020 A
  • Filed: 01/21/1997
  • Issued: 11/10/1998
  • Est. Priority Date: 04/20/1994
  • Status: Expired due to Term
First Claim
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1. A dendrimeric compound or a salt thereof, said compound comprising a biodegradable core moiety and a dendrimeric backbone moiety, wherein said core moiety is a phosphazene or a boron-based core of the formula:

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    space="preserve" listing-type="equation">Y X-Y!.sub.qin which X is carbon, oxygen, or nitrogen, each X, independently, is unsubstituted or substituted with R or Y'"'"'-X'"'"'!q ;

    Y is boron or phosphorus, each Y, independently, is unsubstituted or substituted with R or X'"'"'-Y'"'"'!q ;

    X'"'"' and Y'"'"' are as defined for X and Y, respectively, but cannot carry side chains Y'"'"'-X'"'"'!q or X'"'"'-Y'"'"'!q ;

    each R, independently, is hydrogen, oxo, or a bond; and

    q is 2-5; and

    two non-adjacent Y groups can together represent a single Y group thereby, together with the intervening X and Y groups, creating a 4 to 10 membered ring; and

    said backbone moiety has linked thereto a plurality of diagnostically or therapeutically active moieties, characterised in that the molecular skeleton of said compound contains at least one biodegradable cleavage site such that on cleavage thereof said active moieties are released in renally excretable form.

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