Intramuscular stimulation lead with enhanced infection resistance
First Claim
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1. In a method for making an implantable infection resistant medical electrical lead having a polymeric lead insulator, the insulator providing a cavity with an interior surface surrounding the lead, the improvement comprising:
- providing a graft copolymer on the interior surface of the insulator;
coupling a bioactive agent to the graft copolymer by contacting the graft copolymer on the interior surface with the bioactive agent; and
sealing the cavity of the insulator to prevent free movement of body fluid into the cavity.
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Abstract
To minimize the incidence and consequences of device related infection that occur after prosthetics implants of neuro-muscular stimulating devices, an infection resistant intra-muscular lead has been developed and is disclosed herein. Infection incidence has been decreased by using biomaterials able to release antibacterial drugs (gentamicin) at a controlled rate for the first 3-6 weeks after implant.
92 Citations
26 Claims
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1. In a method for making an implantable infection resistant medical electrical lead having a polymeric lead insulator, the insulator providing a cavity with an interior surface surrounding the lead, the improvement comprising:
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providing a graft copolymer on the interior surface of the insulator; coupling a bioactive agent to the graft copolymer by contacting the graft copolymer on the interior surface with the bioactive agent; and sealing the cavity of the insulator to prevent free movement of body fluid into the cavity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. In a method for making an infection-resistant article having at least one biocompatible surface adapted for use in contact with the body or body constituents, blood or blood products the improvement comprising:
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providing a graft copolymer of acrylamide and acrylic acid on the biocompatible surface such that the graft copolymer comprises 50% to 75% acrylic acid; and ionically coupling a positively charged antimicrobial agent to the graft copolymer by contacting the graft copolymer on the surface with the antimicrobial agent. - View Dependent Claims (19, 20, 21, 23, 24)
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22. A method for making an infection-resistant article having at least one biocompatible surface adapted for use in contact with the body or body constituents, blood or blood products comprising:
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providing a graft copolymer on the biocompatible surface of the article; and ionically coupling a positively charged antimicrobial agent to the graft copolymer by contacting the graft copolymer on the biocompatible surface with the antimicrobial agent; wherein the graft copolymer comprises acrylamide and acrylic acid in a ratio effective to cause sustained release of the bioactive agent from the graft copolymer during a predetermined period following implantation of the article in a body. - View Dependent Claims (25, 26)
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Specification