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Assay for cardiac troponin I

  • US 5,834,220 A
  • Filed: 09/28/1995
  • Issued: 11/10/1998
  • Est. Priority Date: 05/17/1993
  • Status: Expired due to Term
First Claim
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1. An assay for quantitation of cardiac troponin I in a human biological fluid, comprising:

  • a. incubating sequentially or simultaneously;

    i) a sample of the human biological fluid;

    ii) antibody or antibody fragment specific for all or an antibody-reactive portion of the cardiac troponin I peptide ##STR5## iii) troponin C or a troponin I-binding fragment thereof, under conditions which allow the formation of a ternary complex of troponin I in the sample, the antibody and the troponin C;

    b. separating the ternary complex from the sample; and

    c. detecting the formation of the ternary complex as indicative of the amount of cardiac troponin I in the human biological fluid.

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